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Otx2 - orthodenticle homeobox 2 Gene

Also Known as E130306E05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18424

Summary

This gene encodes a protein that belongs to the homeobox family of transcription factors. The encoded protein plays a role in the development and patterning of the head. This protein regulates development of the choroid plexuses in the brain affecting composition of cerebrospinal fluid in the developing brain and is thought to function in the development of sense organs in the embryo. In humans, mutations in this gene are associated with pituitary hormone deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

Otx2 Products (6)

mRNA	Protein	Name
NM_001286481.1	NP_001273410.1	homeobox protein OTX2 isoform a
NM_001286482.1	NP_001273411.1	homeobox protein OTX2 isoform b
NM_001286483.1	NP_001273412.1	homeobox protein OTX2 isoform b
NM_001360225.1	NP_001347154.1	homeobox protein OTX2 isoform a
NM_001360226.1	NP_001347155.1	homeobox protein OTX2 isoform a
NM_144841.5	NP_659090.1	homeobox protein OTX2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15105370	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	14625556	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9501024	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15105370	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	11731459	MGI
acts upstream of or within diencephalon morphogenesis	IGI IGI: Inferred from genetic interaction	20816794	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	15888661	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	12652306	MGI
acts upstream of or within endoderm development	IGI IGI: Inferred from genetic interaction	11412024	MGI
acts upstream of or within eye photoreceptor cell fate commitment	IMP IMP: Inferred from mutant phenotype	14625556	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	15201223	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	14625556	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	10225993	MGI
acts upstream of mesendoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within metencephalon development	IGI IGI: Inferred from genetic interaction	20816794	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	15201224	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	15201223	MGI
acts upstream of or within neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	14625556	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	16339193	MGI
acts upstream of or within neuron fate determination	IMP IMP: Inferred from mutant phenotype	19592574	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	15888661	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	26166575	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16539743	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15890343	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15105370	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	11291865	MGI
acts upstream of or within telencephalon regionalization	IMP IMP: Inferred from mutant phenotype	26166575	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10891582	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10891582	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	26494787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein OTX2	orthodenticle homolog 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09880	OTX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Otx2	NCBI	NCBI:5015