ENO2 - enolase 2 Gene
Also Known as NSE; HEL-S-279
Species: Homo sapiens
About ENO2
This gene has 14 transcripts (splice variants), 260 orthologues and 3 paralogues. Biased expression in brain (RPKM 167.6), adrenal (RPKM 26.3) and 9 other tissues.
Summary
ENO2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001975.3 | NP_001966.1 | gamma-enolase |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21044950 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in membrane |
IDA
IDA: Inferred from direct assay
|
19433310 | GOA |
ENO2 Protein Structure
Enolase_N: Enolase, N-terminal domain (3 - 134)
Enolase_C: Enolase, C-terminal TIM barrel domain (143 - 431)
- 0
- 100
- 200
- 300
- 400
- 434 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
gamma-enolase |
|
ENO2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ENO2 | P09104 | ENO1 | Homo sapiens | P06733 | 33961781 | |
|
Intra
|
ENO2 | P09104 | ENO1 | Homo sapiens | P06733 | 28514442 | |
|
Intra
|
ENO2 | P09104 | TINF2 | Homo sapiens | Q9BSI4 | 21044950 |
Recombinant ENO2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70271 | Gamma-enolase/Enolase 2 Protein, Human (His) | P09104-1 (M1-L434) | ≥ 95%, as determined by reducing SDS-PAGE. |
ENO2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81290 | NSE Antibody (YA1004) | WB, ELISA | Human, Mouse, Rat |
| HY-P81290A | NSE Antibody (YA1005) | WB, ELISA | Human, Mouse, Rat |
| HY-P81290AA | NSE Antibody (YA1005)(PBS only) | WB, ELISA | Human, Mouse, Rat |
| HY-P81290B | NSE Antibody (YA1006) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Granular Cell Tumor |
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| Creutzfeldt-Jakob Disease |
|
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| Olfactory Neuroblastoma |
|
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| Bronchus Cancer |
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| Neuroendocrine Carcinoma |
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| Hemangioblastoma |
|
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| Small Cell Osteogenic Sarcoma |
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| Merkel Cell Carcinoma |
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| Carcinoid Tumors, Intestinal |
|
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| Large Cell Carcinoma |
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| Spondylosis |
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| Neuroendocrine Tumor |
|
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| Optic Nerve Glioma |
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| Ganglioglioma |
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| Cardiac Arrest |
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| Status Epilepticus |
|
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| Alveolar Soft Part Sarcoma |
|
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| Melanotic Neuroectodermal Tumor |
|
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| Myoblastoma |
|
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| Neonatal Hypoxic And Ischemic Brain Injury |
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| Paraganglioma |
|
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| Post-Cardiac Arrest Syndrome |
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| Neuroma |
|
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| Gastric Small Cell Carcinoma |
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| Teratoma |
|
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| Endometrial Small Cell Carcinoma |
|
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| Childhood Ovarian Dysgerminoma |
|
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| Childhood Ovarian Germ Cell Tumor |
|
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| Ewing Sarcoma |
|
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| Olfactory Neural Tumor |
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| Malignant Olfactory Nerve Neoplasm |
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| Cauda Equina Neoplasm |
|
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| Esophagus Small Cell Carcinoma |
|
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| Dysgerminoma |
|
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| Mesenchymal Chondrosarcoma |
|
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| Ganglioneuroma |
|
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| Secondary Progressive Multiple Sclerosis |
|
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| Subependymal Giant Cell Astrocytoma |
|
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| Lambert-Eaton Myasthenic Syndrome |
|
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| Seminoma |
|
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| Nasal Cavity Cancer |
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| Somatostatinoma |
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| Glomus Tumor |
|
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| Congenital Epulis |
|
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| Ganglioneuroblastoma |
|
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| Gastrointestinal Stromal Tumor |
|
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| Small Cell Cancer Of The Lung |
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| Epulis |
|
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| Leiomyosarcoma |
|
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| Malignant Melanocytic Neoplasm Of The Peripheral Nerve Sheath |
|
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| Cranial Nerve Malignant Neoplasm |
|
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| Cerebral Neuroblastoma |
|
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| Peripheral Nervous System Benign Neoplasm |
|
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| Autonomic Nervous System Benign Neoplasm |
|
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| Vulvar Granular Cell Tumor |
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| Sertoli-Leydig Cell Tumor |
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| Pilomatrixoma |
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| Anal Neuroendocrine Tumor |
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| Pheochromocytoma |
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| Askin'S Tumor |
|
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| Lung Cancer |
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| Middle Ear Adenoma |
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| Auditory System Benign Neoplasm |
|
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| Bladder Small Cell Carcinoma |
|
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| Hemiplegia |
|
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| Malignant Granular Cell Myoblastoma |
|
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| Scrapie |
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| Congenital Granular Cell Tumor |
|
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| Transitional Cell Carcinoma |
|
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| Cloacogenic Carcinoma |
|
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| Benign Teratoma |
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| Sensory Organ Benign Neoplasm |
|
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| Optic Nerve Astrocytoma |
|
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| Thymus Small Cell Carcinoma |
|
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| Chondroblastoma |
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| Goblet Cell Carcinoid |
|
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| Germ Cell Cancer |
|
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| Neurilemmoma |
|
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| Neuronal Intestinal Dysplasia, Type B |
|
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| Breast Neuroendocrine Neoplasm |
|
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| Malignant Teratoma |
|
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| Auditory System Cancer |
|
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| Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor |
|
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| Carotid Body Cancer |
|
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| Desmoplastic Small Round Cell Tumor |
|
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| Cerebellar Medulloblastoma |
|
|
| Sertoli Cell Tumor |
|
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| Chondrosarcoma |
|
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| Pleurisy |
|
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| Large Cell Neuroendocrine Carcinoma |
|
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| Ureter Small Cell Carcinoma |
|
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| Rhabdomyosarcoma 2 |
|
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| Penis Sarcoma |
|
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| Rhabdomyosarcoma |
|
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| Cervix Small Cell Carcinoma |
|
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| Carcinoid Syndrome |
|
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| Cerebellar Liponeurocytoma |
|
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| Anaplastic Large Cell Lymphoma |
|
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| Urinary Bladder Small Cell Neuroendocrine Carcinoma |
|
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| Cutaneous Ganglioneuroma |
|
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| Ovarian Large-Cell Neuroendocrine Carcinoma |
|
|
| Microcystic Adenoma |
|
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| Akinetic Mutism |
|
|
| Sinonasal Undifferentiated Carcinoma |
|
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| Meningeal Melanocytoma |
|
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| Ewing Sarcoma Of Bone |
|
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| Lung Large Cell Carcinoma |
|
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| Appendicitis |
|
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| Lung Benign Neoplasm |
|
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| Conventional Fibrosarcoma |
|
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| Horner'S Syndrome |
|
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| Large Cell Carcinoma With Rhabdoid Phenotype |
|
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| Adrenal Cortical Adenoma |
|
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| Adrenal Neuroblastoma |
|
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| Tubular Adenocarcinoma |
|
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| Mediastinal Cancer |
|
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| Medulloepithelioma |
|
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| Small Cell Carcinoma |
|
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| Gallbladder Small Cell Carcinoma |
|
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| Oligodendroglioma |
|
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| Hemangioma |
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| Pericarditis |
|
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| Paraneoplastic Cerebellar Degeneration |
|
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| Lyme Disease |
|
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| Central Nervous System Melanocytic Neoplasm |
|
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| Central Nervous System Primitive Neuroectodermal Neoplasm |
|
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| Lung Oat Cell Carcinoma |
|
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| Pleomorphic Adenoma |
|
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| Coats Disease |
|
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| Retinoblastoma |
|
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| Pineocytoma |
|
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| Central Neurocytoma |
|
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| Achalasia |
|
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| Pineal Gland Cancer |
|
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| Extraosseous Ewing Sarcoma |
|
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| Paranasal Sinus Cancer |
|
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| Sarcoma |
|
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| Medulloblastoma |
|
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| Angiomyoma |
|
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| Tuberous Sclerosis |
|
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| Dysentery |
|
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| Prostate Small Cell Carcinoma |
|
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| Plexiform Schwannoma |
|
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| Cerebellum Cancer |
|
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| Parachordoma |
|
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| Intracranial Primitive Neuroectodermal Tumor |
|
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| Asphyxia Neonatorum |
|
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| Vaginal Glandular Tumor |
|
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| Supratentorial Cancer |
|
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| Hydrocephalus |
|
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| Lymphoblastic Lymphoma |
|
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| Ovarian Small Cell Carcinoma |
|
|
| Cerebrum Cancer |
|
|
| Cerebrovascular Benign Neoplasm |
|
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| Meningitis |
|
|
| Myoma |
|
|
| Jejunal Neoplasm |
|
|
| Orbital Cancer |
|
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| Pancreatoblastoma |
|
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| Cerebral Primitive Neuroectodermal Tumor |
|
|
| Ectomesenchymoma |
|
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| Central Nervous System Mesenchymal Non-Meningothelial Tumor |
|
|
| Colon Neuroendocrine Neoplasm |
|
|
| Ampulla Of Vater Benign Neoplasm |
|
|
| Cerebellopontine Angle Primitive Neuroectodermal Tumor |
|
|
| Neurofibromatosis, Type I |
|
|
| Prostate Cancer |
|
|
| Adrenal Carcinoma |
|
|
| Cystic Teratoma |
|
|
| Lung Disease |
|
|
| Extraskeletal Mesenchymal Chondrosarcoma |
|
|
| Stroke, Ischemic |
|
|
| Gliosarcoma |
|
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| Extraosseous Chondrosarcoma |
|
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| Machado-Joseph Disease |
|
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| Differentiating Neuroblastoma |
|
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| Intracranial Embolism |
|
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| Blastoma |
|
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| Atypical Follicular Adenoma |
|
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| Amelanotic Melanoma |
|
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| Pulmonary Large Cell Neuroendocrine Carcinoma |
|
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| Papilloma Of Choroid Plexus |
|
|
| Parietal Lobe Neoplasm |
|
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| Spindle Cell Thymoma |
|
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| Gastrointestinal Neuroendocrine Tumor |
|
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| Prostate Neuroendocrine Neoplasm |
|
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| Neurohypophysis Granular Cell Tumor |
|
|
| Basaloid Squamous Cell Carcinoma |
|
|
| Mature Teratoma Of The Ovary |
|
|
| Pacinian Tumor |
|
|
| Pineoblastoma |
|
|
| Pineal Region Teratoma |
|
|
| Mature Teratoma |
|
|
| Obstructive Hydrocephalus |
|
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| Islet Cell Tumor |
|
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| Myxoid Chondrosarcoma |
|
|
| Neural Tube Defects |
|
|
| Inappropriate Adh Syndrome |
|
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| Pulmonary Neuroendocrine Tumor |
|
|
| Supratentorial Primitive Neuroectodermal Tumor |
|
|
| Perivascular Tumor |
|
|
| Neurofibrosarcoma |
|
|
| Epithelioid Malignant Peripheral Nerve Sheath Tumor |
|
|
| Thyroid Gland Cancer |
|
|
| Malignant Triton Tumor |
|
|
| Gangliocytoma |
|
|
| Adrenal Medulla Cancer |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Nodular Ganglioneuroblastoma |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Breast Granular Cell Tumor |
|
|
| Skin Benign Neoplasm |
|
|
| Mixed Germ Cell Cancer |
|
|
| Pineal Region Choriocarcinoma |
|
|
| Malignant Pheochromocytoma |
|
|
| Lymphoepithelioma-Like Carcinoma |
|
|
| Small Intestine Benign Neoplasm |
|
|
| Spinal Cancer |
|
|
| Cutaneous Fibrous Histiocytoma |
|
|
| Cerebral Ventricle Cancer |
|
|
| Intracranial Hypertension |
|
|
| Basal Cell Carcinoma |
|
|
| Meningothelial Meningioma |
|
|
| Bile Duct Mucinous Adenocarcinoma |
|
|
| Endobronchial Lipoma |
|
|
| Partial Cryptophthalmia |
|
|
| Neuroblastoma |
|
|
| Connective Tissue Benign Neoplasm |
|
|
| Muscle Cancer |
|
|
| Skeletal Muscle Cancer |
|
|
| Brain Cancer |
|
|
| Embryonal Tumor With Multilayered Rosettes, C19mc-Altered |
|
|
| Tetralogy Of Fallot |
|
|
| Heart Disease |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Benign Ependymoma |
|
|
| Breast Leiomyosarcoma |
|
|
| Mixed Cell Type Cancer |
|
|
| Retroperitoneal Hemangiopericytoma |
|
|
| Fatal Familial Insomnia |
|
|
| Huntington Disease |
|
|
| Spinal Cord Oligodendroglioma |
|
|
| Frontal Lobe Neoplasm |
|
|
| Nasal Cavity Olfactory Neuroblastoma |
|
|
| Lipoma Of Spermatic Cord |
|
|
| Paratesticular Lipoma |
|
|
| Appendix Carcinoid Tumor |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Gastric Body Carcinoma |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Melanoma |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Skin Granular Cell Tumor |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Intracranial Berry Aneurysm |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Lung Combined Large Cell Neuroendocrine Carcinoma |
|
|
| Endobronchial Leiomyoma |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Laryngeal Neuroendocrine Tumor |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Spinocerebellar Ataxia 45 |
|
|
| Embryonal Rhabdomyosarcoma |
|
|
| Paranasal Sinus Lymphoma |
|
|
| Peripheral Nervous System Disease |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
|
| Hypermethioninemia Due To Adenosine Kinase Deficiency |
|
|
| Bone Osteosarcoma |
|
|
| Wilms Tumor 1 |
|
|
| Meningioma, Familial |
|
|
| Hirschsprung Disease 1 |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | ENO2 | RGD | RGD:2554 |
| Canis familiaris | ENO2 | VGNC | VGNC:40366 |
| Felis catus | ENO2 | VGNC | VGNC:61866 |
| Macaca mulatta | ENO2 | VGNC | VGNC:72219 |
| Bos taurus | ENO2 | VGNC | VGNC:28497 |
| Mus musculus | ENO2 | MGD | MGI:95394 |
| Others | ENO2 | NCBI |