Mkx - mohawk homeobox Gene

Also Known as Irxl1; 9430023B20Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 210719

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including Collagen fibril organization; regulation of gene expression; and tendon development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human MKX (mohawk homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Mkx Products (1)

mRNA	Protein	Name
NM_177595.4	NP_808263.2	homeobox protein Mohawk

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22923612	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22923612	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19235719	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22923612	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22923612	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22923612	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19235719	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19235719	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	20696843	MGI
involved in muscle organ development	IEP IEP: Inferred from expression pattern	16408284	MGI
acts upstream of or within negative regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	19235719	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19235719	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22923612	MGI
acts upstream of or within positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	20498044	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20696843	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22923612	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20498044	MGI
acts upstream of or within tendon cell differentiation	IMP IMP: Inferred from mutant phenotype	20696843	MGI
acts upstream of or within tendon formation	IMP IMP: Inferred from mutant phenotype	20498044	MGI
acts upstream of or within tendon sheath development	IMP IMP: Inferred from mutant phenotype	20696843	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein Mohawk	iroquois homeobox protein-like 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08483	MKX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22081	Mkx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28601	Mkx Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mkx	NCBI	NCBI:283078