Mlx - MAX-like protein X Gene

Also Known as Tf4; Tcfl4; bHLHd13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21428

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Acts upstream of or within nucleocytoplasmic transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Apr 2022]

Mlx Products (3)

mRNA Protein Name
NM_001159384.1 NP_001152856.1 max-like protein X isoform alpha
NM_001159385.1 NP_001152857.1 max-like protein X isoform beta
NM_011550.3 NP_035680.3 max-like protein X isoform gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
18606808 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12446771 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within nucleocytoplasmic transport IDA
IDA: Inferred from direct assay
12446771 MGI
involved in positive regulation of glycolytic process IDA
IDA: Inferred from direct assay
14742444 MGI
involved in positive regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
14742444 MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
IDA: Inferred from direct assay
14742444 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12446771 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
18606808 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12446771 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

max-like protein X

  • BigMax alpha

  • MAX-like bHLHZIP protein

  • protein BigMax

  • transcription factor-like 4

  • transcription factor-like protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08503 MLX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08505 MLXIPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21156 Mlxipl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlx NCBI NCBI:6945