NSUN6 - NOP2/Sun RNA methyltransferase 6 Gene

Also Known as NOPD1; ARL5B-AS1; 4933414E04Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221078

About NSUN6

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:18,545,561-18,659,327 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues.

Summary

Enables tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NSUN6 Products (5)

mRNA	Protein	Name
NM_001351115.2	NP_001338044.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 2
NM_001351116.2	NP_001338045.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 3
NM_001351117.2	NP_001338046.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 4
NM_001351118.2	NP_001338047.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 5
NM_182543.5	NP_872349.1	tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables tRNA (cytidine-5-)-methyltransferase activity	EXP EXP: Inferred from Experiment	26160102	GOA
enables tRNA (cytidine-5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	26160102	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	26160102	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tRNA C5-cytosine methylation	IDA IDA: Inferred from direct assay	26160102	GOA
involved in tRNA methylation	IDA IDA: Inferred from direct assay	28531330	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	37226891	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26160102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSUN6 Protein Structure

Methyltr_RsmB-F

0
100
200
300
400
469 a.a.

Protein Preferred Names	Protein Names
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6	ARL5B antisense RNA 1

NSUN6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86993	NSUN6 Antibody (YA6686)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dubowitz Syndrome	Dubowitz'S Syndrome Dwarfism-Eczema-Peculiar Facies Syndrome Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09605	NSUN6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22694	Nsun6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29208	Nsun6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NSUN6	VGNC	VGNC:43992
Bos taurus	NSUN6	VGNC	VGNC:32287
Mus musculus	NSUN6	MGD	MGI:1921705
Rattus norvegicus	NSUN6	RGD	RGD:1309535
Felis catus	NSUN6	VGNC	VGNC:63895
Macaca mulatta	NSUN6	VGNC	VGNC:75452
Others	NSUN6	NCBI