Wfs1 - wolframin ER transmembrane glycoprotein Gene

Also Known as wolframin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22393

Summary

Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER Transmembrane Glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Wfs1 Products (1)

mRNA Protein Name
NM_011716.2 NP_035846.1 wolframin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IDA
IDA: Inferred from direct assay
17947299 MGI
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
20160352 MGI
involved in endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
16571599 MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16571599 MGI
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
19911006 MGI
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16087305 MGI
involved in positive regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
19911006 MGI
involved in positive regulation of growth IMP
IMP: Inferred from mutant phenotype
19293327 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
20160352 MGI
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20160352 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
15994758 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16087305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

wolframin

  • Wolfram syndrome 1 homolog

  • Wolfram syndrome 1 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137605 WSF1-IN-1 Inhibitor 99.91% Unkown
HY-181649 S1R agonist 3 Agonist / Unkown
HY-RS15813 WFS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18644 Wfs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25129 Wfs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wfs1 NCBI NCBI:7466