Glis3 - GLIS family zinc finger 3 Gene

Also Known as 4833409N03Rik; E330013K21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226075

Summary

This gene is a member of the GLI-similar Zinc Finger Protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of Insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

Glis3 Products (3)

mRNA Protein Name
NM_001305671.1 NP_001292600.1 zinc finger protein GLIS3 isoform 2
NM_001404124.1 NP_001391053.1 zinc finger protein GLIS3 isoform 1
NM_175459.6 NP_780668.3 zinc finger protein GLIS3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14500813 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14500813 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14500813 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14500813 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
19264802 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14500813 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18298960 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14500813 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14500813 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19264802 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14500813 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14500813 MGI
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14500813 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14500813 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein GLIS3

  • GLI-similar 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05476 GLI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05482 GLIS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21349 Gli3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27868 Gli3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29495 Glis3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glis3 NCBI NCBI:169792