Cxcr1 - chemokine (C-X-C motif) receptor 1 Gene

Also Known as Il8ra

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227288

About Cxcr1

Chromosome 1: 74,230,944-74,233,790 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 232 orthologues, 25 paralogues and is associated with 10 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable chemokine binding activity and Chemokine Receptor activity. Predicted to be involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and receptor internalization. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in bone marrow and lung. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease; pyelonephritis; and urinary tract Infection. Orthologous to human CXCR1 (C-X-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr1 Products (1)

mRNA Protein Name
NM_178241.5 NP_839972.1 C-X-C chemokine receptor type 1

Cxcr1 Protein Structure

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (44 - 320)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (44 - 71)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (78 - 103)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (114 - 144)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (155 - 177)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (203 - 231)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (239 - 269)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (288 - 313)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 1

  • CXC chemokine receptor 1

  • high affinity interleukin-8 receptor A

  • interleukin 8 receptor, alpha

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-15251 Reparixin Inhibitor 99.99% Phase 3
HY-15252 Reparixin L-lysine salt Inhibitor 99.87% Phase 3
HY-19519A Ladarixin sodium Antagonist 99.84% Phase 3
HY-10198 Navarixin Antagonist 99.33% Phase 2
HY-119339 SX-682 Inhibitor 99.64% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12927 SX-517 Antagonist 99.90% Unkown
HY-10011 SCH 563705 Antagonist 99.86% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-120878 CXCR2-IN-2 Antagonist 99.52% Unkown
HY-114366 BC-1485 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr1 NCBI NCBI:3577