Pik3c2b - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

Also Known as Gm199; PI3KC2beta; PI3K-C2beta; C330011J12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 240752

About Pik3c2b

Chromosome 1: 132,973,405-133,036,425 forward strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in colon adult (RPKM 14.), spleen adult (RPKM 1.9) and 24 other tissues.

Summary

Enables lipid kinase activity. Acts upstream of or within several processes, including autophagosome organization; phosphatidylinositol-3-phosphate biosynthetic process; and protein kinase B signaling. Located in endocytic vesicle. Is expressed in eye; limb; nervous system; and skeleton. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2b Products (1)

mRNA Protein Name
NM_001099276.2 NP_001092746.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipid kinase activity IDA
IDA: Inferred from direct assay
17875942 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17875942 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagosome organization IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within cellular response to starvation IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within macroautophagy IGI
IGI: Inferred from genetic interaction
24098492 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
17875942 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IGI
IGI: Inferred from genetic interaction
24098492 MGI
Cellular Component GO Annotation Evidence References Source
located in endocytic vesicle IDA
IDA: Inferred from direct assay
17875942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c2b Protein Structure

PI3K_rbd

PI3K_rbd: pfam00794 (362 - 464)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (620 - 792)

PI3Ka_II

PI3Ka_II: cd00869 (811 - 979)

PI3Kc_C2_beta

PI3Kc_C2_beta: cd00895 (985 - 1338)

PX_PI3K_C2_beta

PX_PI3K_C2_beta: cd07290 (1367 - 1475)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1503 - 1625)

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  • 1632 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

  • phosphoinositide-3-kinase, class 2, beta polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112608 CHMFL-PI3KD-317 Inhibitor 98.04% Unkown
HY-RS10514 PIK3C2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10515 Pik3c2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10516 Pik3c2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c2b NCBI NCBI:5287