PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

Homo sapiens

Also known as C2-PI3K

Gene ID: 5287 | Gene type: protein coding

About PIK3C2B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,422,633-204,494,805 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 8.8), skin (RPKM 7.4) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind Phospholipids but not Ca2+, which suggests that this Enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

PIK3C2B Products(3)

mRNA	Protein	Name
NM_001377334.1	NP_001364263.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 1
NM_001377335.1	NP_001364264.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 2
NM_002646.4	NP_002637.3	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 1

PIK3C2B Protein Structure

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
300
600
900
1200
1500
1634 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

PI3K-C2-beta	PI3K-C2beta
PTDINS-3-kinase C2 beta	phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide
phosphoinositide 3-kinase-C2-beta	phosphoinositide-3-kinase, class 2, beta polypeptide
ptdIns-3-kinase C2 subunit beta

Related Diseases

Diseases

Alias

Peliosis Hepatis

Hepatic Peliosis	Telangiectasis Of Liver
Angiomatosis Of Liver	Ph - [Peliosis Hepatis]
Hepatic Angiomatosis

Centronuclear Myopathy

Myopathy, Centronuclear	Myotubular Myopathy
Cnm	Myopathy, Myotubular
Congenital Structural Myopathy

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112608	CHMFL-PI3KD-317	Inhibitor	98.04%	Unkown
HY-RS10514	PIK3C2B Human Pre-designed siRNA Set A		/	Unkown
HY-RS10515	Pik3c2b Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10516	Pik3c2b Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PIK3C2B	VGNC	VGNC:68851
Canis familiaris	PIK3C2B	VGNC	VGNC:44552
Macaca mulatta	PIK3C2B	VGNC	VGNC:100035
Bos taurus	PIK3C2B	VGNC	VGNC:32886
Rattus norvegicus	PIK3C2B	RGD	RGD:1306541
Mus musculus	PIK3C2B	MGD	MGI:2685045

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