PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

Also Known as C2-PI3K

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5287

About PIK3C2B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,422,633-204,494,805 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 8.8), skin (RPKM 7.4) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind Phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

PIK3C2B Products (3)

mRNA Protein Name
NM_001377334.1 NP_001364263.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 1
NM_001377335.1 NP_001364264.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 2
NM_002646.4 NP_002637.3 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
9830063 GOA
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
IDA: Inferred from direct assay
9830063 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10805725 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9830063 GOA
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
9830063 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9830063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C2B Protein Structure

PI3K_rbd

PI3K_rbd: PI3-kinase family, ras-binding domain (365 - 465)

PI3K_C2

PI3K_C2: Phosphoinositide 3-kinase C2 (649 - 787)

PI3Ka

PI3Ka: Phosphoinositide 3-kinase family, accessory domain (PIK domain) (812 - 988)

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (1078 - 1290)

PX

PX: PX domain (1367 - 1476)

C2

C2: C2 domain (1520 - 1607)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1634 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

  • PI3K-C2-beta

  • PI3K-C2beta

  • PTDINS-3-kinase C2 beta

  • phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide

  • phosphoinositide 3-kinase-C2-beta

  • phosphoinositide-3-kinase, class 2, beta polypeptide

  • ptdIns-3-kinase C2 subunit beta

Related Diseases

Diseases Alias
Peliosis Hepatis

  • Hepatic Peliosis

  • Telangiectasis Of Liver

  • Angiomatosis Of Liver

  • Ph - [Peliosis Hepatis]

  • Hepatic Angiomatosis
Centronuclear Myopathy

  • Myopathy, Centronuclear

  • Myotubular Myopathy

  • Cnm

  • Myopathy, Myotubular

  • Congenital Structural Myopathy
Myopathy, Centronuclear, X-Linked

  • X-Linked Myotubular Myopathy

  • Xlmtm

  • X-Linked Centronuclear Myopathy

  • Xlcnm

  • CNMX

  • Mtm1

  • Myotubular Myopathy, X-Linked

  • Mtmx

  • Myotubular Myopathy 1

  • Centronuclear Myopathy X-Linked

  • Myotubular Myopathy

  • Mtm

  • Cnm

  • Xmtm

  • Myotubular Myopathy Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112608 CHMFL-PI3KD-317 Inhibitor 98.04% Unkown
HY-RS10514 PIK3C2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10515 Pik3c2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10516 Pik3c2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIK3C2B VGNC VGNC:68851
Canis familiaris PIK3C2B VGNC VGNC:44552
Macaca mulatta PIK3C2B VGNC VGNC:100035
Bos taurus PIK3C2B VGNC VGNC:32886
Rattus norvegicus PIK3C2B RGD RGD:1306541
Mus musculus PIK3C2B MGD MGI:2685045
Others PIK3C2B NCBI