Add2 - adducin 2 Gene

Also Known as beta-ADD

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24171

Summary

Predicted to enable cytoskeletal protein binding activity; protein dimerization activity; and protein kinase binding activity. Predicted to be a structural constituent of Cytoskeleton. Involved in ion transport. Is active in glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2). [provided by Alliance of Genome Resources, Apr 2022]

Add2 Products (2)

mRNA Protein Name
NM_001109880.1 NP_001103350.1 beta-adducin isoform a
NM_012491.2 NP_036623.1 beta-adducin isoform b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
2059221 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9679146 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
9679146 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-adducin

  • adducin 2 (beta)

  • adducin beta

  • adducin-63

  • erythrocyte adducin subunit beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00339 ADD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18905 Add2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25396 Add2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add2 NCBI NCBI:119