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Nr3c1 - nuclear receptor subfamily 3, group C, member 1 Gene

Also Known as GR; Gcr; Grl

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24413

About Nr3c1

Primary_assembly 18: 31,271,681-31,393,375 reverse strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 280 orthologues, 8 paralogues and is associated with 63 phenotypes. Biased expression in Lung (RPKM 441.4), Muscle (RPKM 375.5) and 9 other tissues.

Summary

Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to magnesium ion; chromatin organization; and response to glucocorticoid. Located in cytoplasm; dendritic spine; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with nucleus. Used to study several diseases, including asthma; congestive heart failure; hypertension; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal disease; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c1 Products (2)

mRNA	Protein	Name
NM_012576.2	NP_036708.2	glucocorticoid receptor
NM_012576.2	NP_036708.2	glucocorticoid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	8618925	RGD
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	17177174	RGD
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	17177174	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21664419	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	15808513	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables heat shock protein binding	IDA IDA: Inferred from direct assay	12145311	RGD
enables hormone binding	IPI IPI: Inferred from physical interaction	21325249	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9892017	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12672265	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18261979	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8618925	RGD
enables steroid binding	IPI IPI: Inferred from physical interaction	12145311	RGD
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12145311	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in androgen metabolic process	IEP IEP: Inferred from expression pattern	8809674	RGD
involved in cellular response to dexamethasone stimulus	IMP IMP: Inferred from mutant phenotype	12145311	RGD
involved in cellular response to magnesium ion	IEP IEP: Inferred from expression pattern	20350433	RGD
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	12917342	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	16673181	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21744335	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	16371448	RGD
involved in muscle atrophy	IEP IEP: Inferred from expression pattern	17622304	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16175607	RGD
involved in negative regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	22918985	RGD
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	7648494	RGD
involved in nuclear receptor-mediated corticosteroid signaling pathway	IDA IDA: Inferred from direct assay	10399770	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	22989630	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	22509272	RGD
involved in positive regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	22001115	RGD
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	19484722	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15310238	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12145311	RGD
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16115202	RGD
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	17292727	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	17557067	RGD
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	15310238	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	22142627	RGD
involved in response to corticosterone	IDA IDA: Inferred from direct assay	10399770	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	16673181	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	21804312	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	22040414	RGD
involved in response to inactivity	IEP IEP: Inferred from expression pattern	22036623	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	16646523	RGD
involved in response to mercury ion	IEP IEP: Inferred from expression pattern	17177174	RGD
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	12917342	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	21179518	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21179518	RGD
located in nucleus	IDA IDA: Inferred from direct assay	17827210	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	21179518	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12672265	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c1 Protein Structure

GCR

NR_DBD_GR_PR

NR_LBD_GR

0
200
400
600
795 a.a.

Protein Preferred Names	Protein Names
glucocorticoid receptor

Nr3c1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Nr3c1	P06536	SMARCA4	Homo sapiens	P51532	Anti Bait CoIP	12917342
Cross	Nr3c1	P06536	NCOA1	Homo sapiens	Q15788	Anti Bait CoIP	12917342
Cross	Nr3c1	P06536	NCOA1	Homo sapiens	Q15788	Pull Down	12917342
Intra	Nr3c1	P06536	Ntrk2	Rattus norvegicus	Q63604	Anti Bait CoIP	19126684
Intra	Nr3c1	P06536	Mvp	Rattus norvegicus	Q62667	Anti Bait CoIP	16619302

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-RS09544	NR3C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09545	Nr3c1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09546	Nr3c1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr3c1	NCBI	NCBI:2908