NR3C1 - nuclear receptor subfamily 3 group C member 1 Gene

Also Known as GR; GCR; GRL; GCCR; GCRST

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2908

About NR3C1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:143,277,931-143,435,512 (from NCBI)

This gene has 17 transcripts (splice variants), 280 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 11.8), lung (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes Glucocorticoid Receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of Other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

NR3C1 Products (22)

mRNA	Protein	Name
NM_001204264.2	NP_001191193.1	glucocorticoid receptor isoform alpha-D3
NM_001204261.2	NP_001191190.1	glucocorticoid receptor isoform alpha-C3
NM_001204263.2	NP_001191192.1	glucocorticoid receptor isoform alpha-D2
NM_001020825.2	NP_001018661.1	glucocorticoid receptor isoform beta
NM_001364183.2	NP_001351112.1	glucocorticoid receptor isoform gamma
NM_001364180.2	NP_001351109.1	glucocorticoid receptor isoform alpha
NM_001204258.2	NP_001191187.1	glucocorticoid receptor isoform alpha-B
NM_001204262.2	NP_001191191.1	glucocorticoid receptor isoform alpha-D1
NM_000176.3	NP_000167.1	glucocorticoid receptor isoform alpha
NM_001204265.2	NP_001191194.1	glucocorticoid receptor isoform GR-P
NM_001364182.1	NP_001351111.1	glucocorticoid receptor isoform alpha
NM_001018076.2	NP_001018086.1	glucocorticoid receptor isoform alpha
NM_001364185.1	NP_001351114.1	glucocorticoid receptor isoform gamma
NM_001018075.1	NP_001018085.1	glucocorticoid receptor isoform alpha
NM_001364181.2	NP_001351110.1	glucocorticoid receptor isoform alpha
NM_001018077.1	NP_001018087.1	glucocorticoid receptor isoform alpha
NM_001018074.1	NP_001018084.1	glucocorticoid receptor isoform alpha
NM_001204260.2	NP_001191189.1	glucocorticoid receptor isoform alpha-C2
NM_001204259.2	NP_001191188.1	glucocorticoid receptor isoform alpha-C1
NM_001364184.2	NP_001351113.1	glucocorticoid receptor isoform gamma
NR_157096.2
NM_001024094.2	NP_001019265.1	glucocorticoid receptor isoform gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16728402	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15769988	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1894621	GOA
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	26593036	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16728402	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1894621	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	19841061	GOA
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17081986	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	17635946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9079630	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20371704	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables steroid binding	IDA IDA: Inferred from direct assay	15769988	GOA
enables steroid hormone binding	IDA IDA: Inferred from direct assay	17635946	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to dexamethasone stimulus	IMP IMP: Inferred from mutant phenotype	12902338	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	9353307	GOA
involved in cellular response to steroid hormone stimulus	IDA IDA: Inferred from direct assay	15769988	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	12902338	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1894621	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1894621	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12902338	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	27334923	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15769988	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9353307	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17081986	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15769988	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	9353307	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28139699	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9353307	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26593036	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR3C1 Protein Structure

GCR

zf-C4

Hormone_recep

0
200
400
600
777 a.a.

Protein Preferred Names	Protein Names
glucocorticoid receptor	nuclear receptor subfamily 3 group C member 1 variant hGR-B(54) nuclear receptor subfamily 3 group C member 1 variant hGR-B(77) nuclear receptor subfamily 3 group C member 1 variant hGR-B(93) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NR3C1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR3C1	P04150	LCK	Homo sapiens	P06239	Anti Bait CoIP	16888650
Intra	NR3C1	P04150	HSP90AA1	Homo sapiens	P07900	EM	24949977
Intra	NR3C1	P04150	HSP90AA1	Homo sapiens	P07900	MAPPIT	31467278
Intra	NR3C1	P04150	HSP90AA1	Homo sapiens	P07900	Pull Down	24949977
Intra	NR3C1	P04150	HSP90AA1	Homo sapiens	P07900	GMS	24949977
Intra	NR3C1	P04150	HSP90AA1	Homo sapiens	P07900	Crosslink	24949977
Intra	NR3C1	P04150	AKT1	Homo sapiens	P31749	Pull Down	24291004
Intra	NR3C1	P04150	AKT1	Homo sapiens	P31749	Protein Kinase Assay	24291004
Intra	NR3C1	P04150	AKT1	Homo sapiens	P31749	Anti Tag CoIP	24291004
Intra	NR3C1	P04150	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	NR3C1	P04150	CD4	Homo sapiens	P01730	Anti Bait CoIP	16888650
Intra	NR3C1	P04150	KIAA0408	Homo sapiens	Q6ZU52	Display Tech	20195357
Intra	NR3C1	P04150	RXRB	Homo sapiens	P28702	Y2H Array	20211142
Cross	NR3C1	P04150	Mvp	Rattus norvegicus	Q62667	Y2H	16619302
Cross	NR3C1	P04150	Mvp	Rattus norvegicus	Q62667	Pull Down	16619302

Cross: Cross-species interaction Intra: Intraspecies interaction

NR3C1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80143	Glucocorticoid Receptor alpha Antibody (YA754)	WB, IHC-P, FC, ICC/IF	Human, Mouse
HY-P80687	Glucocorticoid Receptor Antibody (YA412)	WB, ICC/IF	Human, Mouse, Rat
HY-P80687A	Glucocorticoid Receptor Antibody (YA412)(PBS only)	WB, ICC/IF	Human, Mouse, Rat
HY-P82850	Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)	WB, IHC-P	Human, Rat
HY-P82850A	Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)(PBS only)	WB, IHC-P	Human, Rat
HY-P85192	Glucocorticoid Receptor Antibody (YA4884)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P86539	Glucocorticoid Receptor Antibody (YA6231)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Cushing'S Disease Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Nelson Syndrome	Nelson'S Syndrome Dermal Ridges Ridges-Off-The-End Syndrome Postadrenalectomy Cushing Syndrome
Pseudohypoaldosteronism
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Alzheimer Disease 16	AD16 Alzheimer'S Disease 16 Alzheimer'S Disease 16, Late Onset
Hyperandrogenism	Hyperandrogenization Syndrome
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Atypical Depressive Disorder	Atypical Depression
Giant Cell Reparative Granuloma	Central Giant Cell Granuloma Central Giant Cell Reparative Granuloma Of Jaw Central Giant Cell Granuloma Granuloma, Giant Cell Granuloma, Giant Cell Reparative Giant Cell Lesion Of Small Bones Giant Cell Granuloma, Nos
Adult Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Acro Dermato Ungual Lacrimal Tooth Syndrome Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Adult
Generalized Anxiety Disorder	Anxiety Generalized
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Pituitary Adenoma	Pituitary Neoplasms Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma
Rhinitis	Runny Nose
Diabetes Mellitus	Diabetes
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Hyperaldosteronism, Familial, Type I	Glucocorticoid-Remediable Aldosteronism Gra Familial Hyperaldosteronism Type 1 HALD1 Fh I Glucocorticoid-Suppressible Hyperaldosteronism Gsh Acth-Dependent Hyperaldosteronism Syndrome Aldosteronism, Glucocorticoid-Remediable Dexamethasone Sensitive Hypertension Glucocorticoid Sensitive Hypertension Hyperaldosteronism, Familial Type 1 Familial Hyperaldosteronism Type I Fh1 Aldosteronism, Sensitive To Dexamethasone Dexamethasone-Sensitive Hypertension Fh-I Glucocorticoid-Sensitive Hypertension Hyperaldosteronism, Familial, 1 Aldosteronism Sensitive To Dexamethasone Familial Hyperaldosteronism 1 Fh Type 1 Familial Aldosteronism Type I
Glucocorticoid Resistance, Generalized	Glucocorticoid Resistance Glucocorticoid Receptor Deficiency Cortisol Resistance From Glucocorticoid Receptor Defect GCCR Gccr Deficiency Gcr Deficiency Grl Deficiency Generalized Glucocorticoid Resistance Syndrome GCRES Cortisol Resistance Chrousos Syndrome
Adrenal Cortex Disease	Adrenal Cortex Diseases
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Pituitary-Dependent Cushing'S Disease	Pituitary-Dependent Cushing Disease Pituitary Acth Hypersecretion Overproduction Of Acth Pituitary-Dependent Cushings Disease Overproduction Of Pituitary Acth Pituitary-Dependent Hyperadrenocorticism Corticotroph Pituitary Adenoma Acth- [Adrenocorticotropic Hormone] Secreting Pituitary Adenoma Cushing Syndrome Or Disease, Pituitary-Dependent Cushings Basophilism Cushing'S Syndrome 3 Itsenko-Cushing Syndrome Itsenko Disease Pituitary Basophilism Pituitary-Dependent Hypercorticalism Suprarenogenic Syndrome Cushing Disease Cushing'S Disease
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cerebral Angioma	Hemangioma Of Cerebrum Cerebral Hemangioma
Adrenal Gland Disease	Adrenal Gland Diseases Adrenal Gland Disorders
Pylorus Cancer	Ca Pylorus - Stomach Malignant Neoplasm Of Prepylorus Malignant Neoplasm Of Pylorus Of Stomach Malignant Tumor Of Pylorus Malignant Neoplasm Of Pylorus
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Mood Disorder	Mood Disorders Episodic Mood Disorder
Mental Depression	Depression Depressive Disorder
Abnormality Of Glucagon Secretion	Glucagon Secretion Abnormality Abnormality Of Secretion Of Glucagon
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Ovarian Serous Adenofibroma
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Mediastinal Lipomatosis
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Ectopic Cushing Syndrome	Cushing Syndrome Due To Ectopic Acth Secretion Ectopic Acth Secreting Tumor Adrenocorticotropic Hormone Secretion Syndrome Occult Ectopic Acth Secretion Paraneoplastic Cushing Syndrome
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Borderline Personality Disorder
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Steroid-Induced Glaucoma	Corticosteroid-Induced Glaucoma
Corticosteroid-Binding Globulin Deficiency	CBG DEFICIENCY Transcortin Deficiency
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism LIDLS1 Lidls Pseudohyperaldosteronism Liddle'S Syndrome Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-RS09544	NR3C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09545	Nr3c1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09546	Nr3c1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NR3C1	VGNC	VGNC:43952
Macaca mulatta	NR3C1	VGNC	VGNC:75515
Felis catus	NR3C1	VGNC	VGNC:102270
Bos taurus	NR3C1	VGNC	VGNC:32243
Mus musculus	NR3C1	MGD	MGI:95824
Rattus norvegicus	NR3C1	RGD	RGD:2741
Others	NR3C1	NCBI