Ptgs1 - prostaglandin-endoperoxide synthase 1 Gene

Also Known as Cox1; Cox3; Cox-1; Cox-3; Pghs-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24693

Summary

This is one of two genes encoding similar Enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]

Ptgs1 Products (1)

mRNA Protein Name
NM_017043.4 NP_058739.4 prostaglandin G/H synthase 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in learning IMP
IMP: Inferred from mutant phenotype
21701788 RGD
involved in maintenance of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
17704356 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
21701788 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: Inferred from mutant phenotype
18598693 RGD
involved in negative regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
18598693 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
18480553 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17245358 RGD
involved in prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
17673564 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
18584335 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
16983392 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
12657565 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin G/H synthase 1

  • PGH synthase 1

  • PHS 1

  • cyclooxygenase 3

  • cyclooxygenase-1

  • prostaglandin G/H synthase and cyclooxygenase

  • prostaglandin H2 synthase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11392 PTGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19231 Ptgs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25720 Ptgs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgs1 NCBI NCBI:5742