Klrk1 - killer cell lectin like receptor K1 Gene

Also Known as NKG2D; Nkrp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24934

Summary

Predicted to enable several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of apoptotic process; positive regulation of myeloid dendritic cell activation; and positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target. Located in cell surface. Used to study histiocytoma. Human ortholog(s) of this gene implicated in tropical spastic paraparesis. Orthologous to several human genes including KLRC4-KLRK1 (KLRC4-KLRK1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Klrk1 Products (1)

mRNA Protein Name
NM_133512.2 NP_598196.1 NKG2-D type II integral membrane protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16323246 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15048723 RGD
involved in positive regulation of myeloid dendritic cell activation IDA
IDA: Inferred from direct assay
17369187 RGD
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
16323246 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15048723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NKG2-D type II integral membrane protein

  • NK cell receptor D

  • NK lectin-like receptor

  • NKG2-D-activating NK receptor

  • NKLLR

  • NKR-P2, ortholog of human NKG2D

  • killer cell lectin-like receptor subfamily K, member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07399 KLRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17835 Klrk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24303 Klrk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990972 Azerutamig / Unkown
HY-P991003 Ingitamig Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klrk1 NCBI NCBI:22914