Chrna7 - cholinergic receptor nicotinic alpha 7 subunit Gene

Also Known as BTX; NARAD; nAChRa7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25302

Summary

Enables several functions, including acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and enzyme binding activity. Involved in several processes, including dopamine biosynthetic process; neuronal action potential; and regulation of ERK1 and ERK2 cascade. Acts upstream of or within calcium ion transport and regulation of membrane potential. Located in several cellular components, including dendrite; plasma membrane raft; and postsynaptic density. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and glycinergic synapse. Is integral component of postsynaptic specialization membrane; integral component of presynaptic membrane; and integral component of spine apparatus membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 Products (1)

mRNA Protein Name
NM_012832.4 NP_036964.3 neuronal acetylcholine receptor subunit alpha-7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IDA
IDA: Inferred from direct assay
22593058 RGD
enables acetylcholine binding IDA
IDA: Inferred from direct assay
11297818 RGD
enables acetylcholine binding IMP
IMP: Inferred from mutant phenotype
16186249 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: Inferred from direct assay
11222635 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11259617 RGD
enables adenylate cyclase binding IPI
IPI: Inferred from physical interaction
12748066 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10627589 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12244045 RGD
enables scaffold protein binding IDA
IDA: Inferred from direct assay
22593058 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
15044058 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
15044058 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
21540349 RGD
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
15760934 RGD
involved in dopamine biosynthetic process IEP
IEP: Inferred from expression pattern
12438507 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
17055644 RGD
involved in memory IDA
IDA: Inferred from direct assay
17898229 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16282518 RGD
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
20505147 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
15044058 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17898229 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
11404397 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
17379406 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
21762741 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
21762741 RGD
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
11222635 RGD
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
15760934 RGD
involved in regulation of response to drug IDA
IDA: Inferred from direct assay
16282518 RGD
involved in response to acetylcholine IDA
IDA: Inferred from direct assay
16282518 RGD
involved in response to carbamate IEP
IEP: Inferred from expression pattern
15179037 RGD
involved in response to nicotine IDA
IDA: Inferred from direct assay
15801858 RGD
involved in response to nicotine IGI
IGI: Inferred from genetic interaction
11404397 RGD
involved in sensory processing IDA
IDA: Inferred from direct assay
17898229 RGD
involved in synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
15044058 RGD
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
11259617 RGD
located in asymmetric synapse IDA
IDA: Inferred from direct assay
12077196 RGD
located in axon IDA
IDA: Inferred from direct assay
12077196 RGD
is active in cholinergic synapse EXP
EXP: Inferred from Experiment
15044058 RGD
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
15044058 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11297818 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12077196 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
12077196 RGD
is active in glycinergic synapse EXP
EXP: Inferred from Experiment
21762741 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
21762741 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12645078 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11297818 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
21540349 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
24607281 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
11588172 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
11588172 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
12077196 RGD
is active in spine apparatus membrane IDA
IDA: Inferred from direct assay
11588172 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-7

  • C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)

  • bungarotoxin alpha

  • cholinergic receptor, nicotinic, alpha 7 (neuronal)

  • cholinergic receptor, nicotinic, alpha polypeptide 7

  • n

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02672 CHRNA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02659 CHRFAM7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19768 Chrna7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26265 Chrna7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna7 NCBI NCBI:1139