Cacna1a - calcium voltage-gated channel subunit alpha1 A Gene

Also Known as BccA1; rbA-1; Cav2.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25398

Summary

Enables Calmodulin binding activity and high voltage-gated Calcium Channel activity. Involved in several processes, including calcium ion import; regulation of voltage-gated Calcium Channel activity; and sensory perception of pain. Located in perikaryon and plasma membrane. Part of voltage-gated Calcium Channel complex. Is integral component of presynaptic active zone membrane. Used to study childhood absence epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1a Products (1)

mRNA Protein Name
NM_012918.5 NP_037050.3 voltage-dependent P/Q-type calcium channel subunit alpha-1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
15980432 RGD
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
17068255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9303303 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
9593738 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion import IDA
IDA: Inferred from direct assay
21611731 RGD
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
15548655 RGD
involved in calcium ion transport IDA
IDA: Inferred from direct assay
9593738 RGD
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
14673106 RGD
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
14673106 RGD
involved in regulation of voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
17196942 RGD
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
25533484 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10964945 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16736476 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
22683683 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17068255 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
16049183 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent P/Q-type calcium channel subunit alpha-1A

  • BI

  • RBA-I

  • brain calcium channel 1

  • brain calcium channel I

  • brain class A

  • calcium channel alpha 1A

  • calcium channel, L type, alpha-1 polypeptide

  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

  • calcium channel, voltage-dependent, alpha 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01791 CACNA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21232 Cacna1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27749 Cacna1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1a NCBI NCBI:773