Cacna2d1 - calcium voltage-gated channel auxiliary subunit alpha2delta 1 Gene

Also Known as CCHLA2; Cacna2; DHSCCA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25399

Summary

Enables voltage-gated Calcium Channel activity. Involved in calcium ion transport and regulation of ion transmembrane transport. Part of L-type voltage-gated Calcium Channel complex. Is active in glutamatergic synapse. Is anchored component of postsynaptic membrane and anchored component of presynaptic active zone membrane. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Apr 2022]

Cacna2d1 Products (3)

mRNA Protein Name
NM_001110847.1 NP_001104317.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor
NM_001110848.1 NP_001104318.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor
NM_012919.3 NP_037051.2 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19818485 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
11604404 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
25527503 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: Inferred from direct assay
25527503 RGD
involved in calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
25527503 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
20478999 RGD
involved in regulation of membrane repolarization during action potential IDA
IDA: Inferred from direct assay
25527503 RGD
Cellular Component GO Annotation Evidence References Source
part of L-type voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
25527503 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19339603 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
19339603 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
19339603 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
21611731 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel subunit alpha-2/delta-1

  • Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)

  • calcium channel, voltage-dependent, alpha2/delta subunit 1

  • voltage-gated calcium channel subunit alpha-2/delta-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01801 CACNA2D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19290 Cacna2d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25780 Cacna2d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna2d1 NCBI NCBI:781