Anxa5 - annexin A5 Gene

Also Known as LC5; Anx5; CPB-I

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25673

Summary

Enables several functions, including P-type calcium transporter activity; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of Prolactin secretion. Located in several cellular components, including Z disc; intercalated disc; and perikaryon. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). [provided by Alliance of Genome Resources, Apr 2022]

Anxa5 Products (1)

mRNA Protein Name
NM_013132.2 NP_037264.2 annexin A5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables P-type calcium transporter activity IDA
IDA: Inferred from direct assay
9299392 RGD
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
2307675 RGD
enables calcium-dependent phospholipid binding IMP
IMP: Inferred from mutant phenotype
12401794 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12401794 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
1386737 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8667030 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
10329451 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to gonadotropin-releasing hormone IMP
IMP: Inferred from mutant phenotype
18504344 RGD
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
11578147 RGD
involved in negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
20684318 RGD
involved in negative regulation of prolactin secretion IMP
IMP: Inferred from mutant phenotype
15256781 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
15537503 RGD
involved in regulation of flagellated sperm motility IDA
IDA: Inferred from direct assay
20684318 RGD
involved in response to calcium ion IDA
IDA: Inferred from direct assay
8362244 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
9022675 RGD
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
7585827 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8931014 RGD
located in cell projection IDA
IDA: Inferred from direct assay
1833446 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8931014 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
11271515 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
1833446 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8725344 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8931014 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
1833446 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
8931014 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8931014 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

annexin A5

  • Annexin V

  • CBP-I

  • PAP-I

  • PP4

  • VAC-alpha

  • anchorin CII

  • annexin-5

  • calphobindin I

  • endonexin II

  • lipocortin V

  • placental anticoagulant protein 4

  • placental anticoagulant protein I

  • thromboplastin inhibitor

  • vascular anticoagulant-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00765 ANXA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17223 Anxa5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23676 Anxa5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Anxa5 NCBI NCBI:308
Mus musculus Anxa5 NCBI NCBI:11747