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Syt1 - synaptotagmin 1 Gene

Also Known as P65

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25716

Summary

Enables several functions, including Calmodulin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of dopamine secretion; regulation of vesicle-mediated transport; and response to calcium ion. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Syt1 Products (1)

mRNA	Protein	Name
NM_001033680.2	NP_001028852.2	synaptotagmin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12860971	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	12526776	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	15340165	RGD
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	22711810	RGD
enables calcium ion sensor activity	EXP EXP: Inferred from Experiment	24001110	RGD
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	7791877	RGD
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	9830048	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	2333096	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	7791877	RGD
enables identical protein binding	EXP EXP: Inferred from Experiment	38177243	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8621455	RGD
enables molecular condensate scaffold activity	EXP EXP: Inferred from Experiment	38177243	RGD
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	38177243	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12860971	RGD
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	12860971	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	2333096	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8567678	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10397765	RGD
enables syntaxin binding	IDA IDA: Inferred from direct assay	7791877	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	10397765	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	12526776	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	10397765	RGD
enables syntaxin-3 binding	IPI IPI: Inferred from physical interaction	10397765	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	12526776	RGD
involved in detection of calcium ion	IDA IDA: Inferred from direct assay	22229667	RGD
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	38177243	RGD
involved in positive regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	21551071	RGD
involved in positive regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	28370453	RGD
involved in positive regulation of vesicle fusion	IDA IDA: Inferred from direct assay	18508778	RGD
involved in protein heterooligomerization	IPI IPI: Inferred from physical interaction	9830048	RGD
involved in regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	11751925	RGD
involved in regulation of regulated secretory pathway	IMP IMP: Inferred from mutant phenotype	12526776	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	28057568	RGD
involved in regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	24001110	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	18508778	RGD
involved in vesicle docking	IDA IDA: Inferred from direct assay	22229667	RGD
involved in vesicle docking	IMP IMP: Inferred from mutant phenotype	24001110	RGD
involved in vesicle fusion	IDA IDA: Inferred from direct assay	24001110	RGD
involved in vesicle fusion	IMP IMP: Inferred from mutant phenotype	24001110	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10967100	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	11751925	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19730411	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	7298720	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	10397765	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18179895	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	28686803	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	28686803	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	28686803	RGD
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	28686803	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	28686803	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15015935	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	18179895	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	7298720	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synaptotagmin-1	synaptotagmin I sytI

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182539	DD04107	Modulator	/	Unkown
HY-P5043	α-Synuclein (67-78) (human)		/	Unkown
HY-RS14106	SYT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22338	Syt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28860	Syt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt1	NCBI	NCBI:6857