country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

LSM4 - LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Also Known as GRP; YER112W

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25804

About LSM4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,306,236-18,323,076 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 22.8), colon (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

LSM4 Products (2)

mRNA	Protein	Name
NM_001252129.2	NP_001239058.1	U6 snRNA-associated Sm-like protein LSm4 isoform 2
NM_012321.5	NP_036453.1	U6 snRNA-associated Sm-like protein LSm4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PH domain binding	IDA IDA: Inferred from direct assay	15905169	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15905169	GOA
located in membrane	IDA IDA: Inferred from direct assay	15905169	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15905169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM4 Protein Structure

LSM

0
100
139 a.a.

Protein Preferred Names	Protein Names
U6 snRNA-associated Sm-like protein LSm4	LSM4 U6 small nuclear RNA and mRNA degradation associated

LSM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM4	Q9Y4Z0	ZBTB10	Homo sapiens	Q96DT7	Validated Y2H	25416956
Intra	LSM4	Q9Y4Z0	ZBTB10	Homo sapiens	Q96DT7	Y2H Array	25416956
Intra	LSM4	Q9Y4Z0	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	LSM4	Q9Y4Z0	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	25416956
Intra	LSM4	Q9Y4Z0	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	LSM4	Q9Y4Z0	GAS7	Homo sapiens	O60861-1	Y2H Array	32296183
Intra	LSM4	Q9Y4Z0	GAS7	Homo sapiens	O60861-1	Y2H Prey Pooling	32296183
Intra	LSM4	Q9Y4Z0	L3MBTL3	Homo sapiens	Q96JM7	Validated Y2H	25416956
Intra	LSM4	Q9Y4Z0	LSM8	Homo sapiens	O95777	Anti Tag CoIP	33961781
Intra	LSM4	Q9Y4Z0	LSM8	Homo sapiens	O95777	Y2H	15231747
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Y2H Array	21988832
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	33961781
Intra	LSM4	Q9Y4Z0	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	LSM4	Q9Y4Z0	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	LSM4	Q9Y4Z0	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	LSM4	Q9Y4Z0	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	LSM4	Q9Y4Z0	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	LSM4	Q9Y4Z0	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	LSM4	Q9Y4Z0	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70944	LSM4 Protein, Human (His)	Q9Y4Z0 (M1-Q139)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Trombiculiasis
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Tick Infestation	Tick Infestations
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07859	LSM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21368	Lsm4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27887	Lsm4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LSM4	VGNC	VGNC:31056
Canis familiaris	LSM4	VGNC	VGNC:42844
Felis catus	LSM4	VGNC	VGNC:102631
Rattus norvegicus	LSM4	RGD	RGD:1306808
Macaca mulatta	LSM4	VGNC	VGNC:74304
Mus musculus	LSM4	MGD	MGI:1354692
Others	LSM4	NCBI