LSM4 - LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as GRP; YER112W

Gene ID: 25804 | Gene type: protein coding

About LSM4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,306,236-18,323,076 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 22.8), colon (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

LSM4 Products(2)

mRNA	Protein	Name
NM_001252129.2	NP_001239058.1	U6 snRNA-associated Sm-like protein LSm4 isoform 2
NM_012321.5	NP_036453.1	U6 snRNA-associated Sm-like protein LSm4 isoform 1

LSM4 Protein Structure

LSM

0
100
139 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm4

LSM4 U6 small nuclear RNA and mRNA degradation associated

Recombinant LSM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70944	LSM4 Protein, Human (His)	Q9Y4Z0 (M1-Q139)	≥95%

Related Diseases

Diseases

Alias

Trombiculiasis

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Tick Infestation

Tick Infestations

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07859	LSM4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LSM4	VGNC	VGNC:31056
Canis familiaris	LSM4	VGNC	VGNC:42844
Felis catus	LSM4	VGNC	VGNC:102631
Rattus norvegicus	LSM4	RGD	RGD:1306808
Macaca mulatta	LSM4	VGNC	VGNC:74304
Mus musculus	LSM4	MGD	MGI:1354692
Others	LSM4	NCBI