PTPN20 - protein tyrosine phosphatase non-receptor type 20 Gene
Also Known as CT126; PTPN20A; PTPN20B; bA42B19.1; bA142I17.1
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 26095
About PTPN20
Cytogenetic location: 10q11.22
Genomic coordinates (GRCh38): 10:46,911,428-47,003,653 (from NCBI)
This gene has 29 transcripts (splice variants), 190 orthologues and 35 paralogues. Broad expression in testis (RPKM 2.2), adrenal (RPKM 1.4) and 18 other tissues.
Summary
The product of this gene belongs to the family of classical tyrosine-specific Protein tyrosine phosphatases. Many Protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PTPN20 Products (55)
| mRNA | Protein | Name |
|---|---|---|
| NM_001320683.2 | NP_001307612.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 2 |
| NM_001352523.2 | NP_001339452.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 17 |
| NM_001352553.2 | NP_001339482.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 27 |
| NM_001320690.2 | NP_001307619.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 11 |
| NM_001352537.2 | NP_001339466.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 20 |
| NM_001042357.5 | NP_001035816.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 1 |
| NM_001320684.2 | NP_001307613.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 13 |
| NM_001320681.2 | NP_001307610.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 8 |
| NM_001352522.2 | NP_001339451.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 16 |
| NM_001352547.2 | NP_001339476.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 11 |
| NM_001320689.2 | NP_001307618.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 11 |
| NM_001352539.2 | NP_001339468.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 20 |
| NM_001042359.4 | NP_001035818.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 4 |
| NM_001352544.2 | NP_001339473.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 22 |
| NM_001320686.2 | NP_001307615.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 8 |
| NM_001352535.2 | NP_001339464.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 19 |
| NM_001352548.2 | NP_001339477.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 11 |
| NM_001352526.2 | NP_001339455.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001352550.2 | NP_001339479.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 25 |
| NM_001352554.2 | NP_001339483.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 27 |
| NM_001042363.5 | NP_001035822.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 8 |
| NM_001320688.2 | NP_001307617.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 15 |
| NM_001042362.4 | NP_001035821.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 7 |
| NM_001352529.2 | NP_001339458.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001352527.2 | NP_001339456.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001352546.2 | NP_001339475.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 24 |
| NM_001042364.5 | NP_001035823.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 9 |
| NM_001320682.2 | NP_001307611.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 11 |
| NM_001352528.2 | NP_001339457.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001352536.2 | NP_001339465.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 20 |
| NM_001352533.2 | NP_001339462.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 9 |
| NM_001352530.2 | NP_001339459.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001042365.4 | NP_001035824.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 10 |
| NM_001352543.2 | NP_001339472.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 22 |
| NM_001352542.2 | NP_001339471.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 21 |
| NM_001352545.2 | NP_001339474.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 23 |
| NM_001352531.2 | NP_001339460.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 31 |
| NM_001042360.4 | NP_001035819.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 5 |
| NM_001352538.2 | NP_001339467.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 20 |
| NM_001352525.2 | NP_001339454.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001352540.2 | NP_001339469.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 29 |
| NM_001320685.2 | NP_001307614.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 14 |
| NM_001352549.2 | NP_001339478.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 25 |
| NM_001352552.2 | NP_001339481.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 27 |
| NM_001042361.5 | NP_001035820.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 6 |
| NM_001352524.2 | NP_001339453.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 30 |
| NM_001352532.2 | NP_001339461.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 9 |
| NM_001320691.2 | NP_001307620.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 12 |
| NM_001042358.5 | NP_001035817.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 3 |
| NM_001352521.2 | NP_001339450.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 14 |
| NM_001352555.2 | NP_001339484.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 28 |
| NM_001352534.2 | NP_001339463.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 18 |
| NM_001352541.2 | NP_001339470.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 21 |
| NM_001352551.2 | NP_001339480.1 | tyrosine-protein phosphatase non-receptor type 20 isoform 26 |
| NM_015605.9 | NP_056420.3 | tyrosine-protein phosphatase non-receptor type 20 isoform 2 |
PTPN20 Protein Structure
Y_phosphatase
Y_phosphatase: Protein-tyrosine phosphatase (183 - 411)
- 0
- 100
- 200
- 300
- 400
- 420 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tyrosine-protein phosphatase non-receptor type 20 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Leopard Syndrome 1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11422 | PTPN20 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | PTPN20 | MGD | MGI:1196295 |
| Macaca mulatta | PTPN20 | VGNC | VGNC:76523 |
| Canis familiaris | PTPN20 | VGNC | VGNC:45173 |
| Rattus norvegicus | PTPN20 | RGD | RGD:1309812 |
| Others | PTPN20 | NCBI |
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