Abat - 4-aminobutyrate aminotransferase Gene

Also Known as I54; Gabat; Gabaat; Gm9851; Laibat; 9630038C02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 268860

Summary

The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Abat Products (2)

mRNA Protein Name
NM_001170978.1 NP_001164449.1 4-aminobutyrate aminotransferase, mitochondrial isoform 2 precursor
NM_172961.3 NP_766549.2 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
10850552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

4-aminobutyrate aminotransferase, mitochondrial

  • (S)-3-amino-2-methylpropionate transaminase

  • 4-aminobutyrate transaminase

  • GABA aminotransferase

  • GABA transaminase

  • GABA transferase

  • beta-alanine oxoglutarate aminotransferase

  • gamma-amino-N-butyrate transaminase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00036 ABAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18027 Abat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24500 Abat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abat NCBI NCBI:18