DKK2 - dickkopf WNT signaling pathway inhibitor 2 Gene

Also Known as DKK-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27123

About DKK2

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:106,921,802-107,036,313 (from NCBI)

This gene has 4 transcripts (splice variants) and 93 orthologues. Broad expression in lung (RPKM 4.8), ovary (RPKM 3.0) and 14 other tissues.

Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

DKK2 Products (1)

mRNA Protein Name
NM_014421.3 NP_055236.1 dickkopf-related protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21944579 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
11742004 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12857724 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11742004 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DKK2 Protein Structure

Dickkopf_N

Dickkopf_N: Dickkopf N-terminal cysteine-rich region (77 - 129)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

dickkopf-related protein 2

  • dickkopf 2 homolog

DKK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DKK2 Q9UBU2 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
DKK2 Q9UBU2 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
DKK2 Q9UBU2 LRP6 Homo sapiens O75581
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

DKK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810838 DKK2 Antibody (YA10081) WB Human, Mouse

Related Diseases

Diseases Alias
Witkop Syndrome

  • Tooth And Nail Syndrome

  • Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome

  • Tns

  • Ectodermal Dysplasia 3, Witkop Type

  • ECTD3

  • Ectodermal Dysplasia 3, Tooth/Nail Type

  • Tooth-And-Nail Syndrome

  • Dysplasia Of Nails With Hypodontia

  • Nail Dysplasia With Hypodontia

  • Witkop'S Syndrome

  • Hypodontia - Dysplasia Of Nails

  • Hypodontia-Dysplasia Of Nails Syndrome

  • Hypodontia-Nail Dysgenesis Syndrome

  • Hypodontia-Nail Dysgenesis
Bone Disease

  • Bone Diseases

  • Skeletal Disease

  • Skeletal Disorder

  • Disorder Of Skeletal System
Axenfeld-Rieger Syndrome

  • Axenfeld Syndrome

  • Rieger Syndrome

  • Rieger Anomaly

  • Axenfeld Anomaly

  • Anomaly, Rieger'S

  • Hagedoom Syndrome

  • Rgs - Rieger Syndrome

  • Rieger'S Anomaly

  • Goniodysgenesis Hypodontia

  • Iridogoniodysgenesis With Somatic Anomalies

  • Ars

  • Axenfeld And Rieger Anomaly

  • Axra

  • Axrs

  • Rieger Eye Malformation Sequence
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03788 DKK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124841 Gallocyanine / Unkown
HY-RS19891 Dkk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26391 Dkk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992224 Anti-DKK2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DKK2 VGNC VGNC:28080
Canis familiaris DKK2 VGNC VGNC:39970
Mus musculus DKK2 MGD MGI:1890663
Rattus norvegicus DKK2 RGD RGD:1308639
Macaca mulatta DKK2 VGNC VGNC:71802
Felis catus DKK2 VGNC VGNC:107326
Others DKK2 NCBI