Penk - proenkephalin Gene

Also Known as Enk; Penk1; Penk2; Penk-rs

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29237

Summary

Predicted to enable Opioid Receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; general adaptation syndrome, behavioral process; and locomotory exploration behavior. Located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Is active in neuronal dense core vesicle lumen and synaptic vesicle lumen. Used to study heroin dependence. Biomarker of Parkinson's disease; alcohol use disorder; dystonia; and spinal disease. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Apr 2022]

Penk Products (1)

mRNA Protein Name
NM_017139.2 NP_058835.2 proenkephalin-A precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9826786 RGD
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
11595755 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
8584038 RGD
involved in cellular response to virus IEP
IEP: Inferred from expression pattern
8411369 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
8584038 RGD
involved in general adaptation syndrome, behavioral process IEP
IEP: Inferred from expression pattern
23665402 RGD
involved in glial cell proliferation IEP
IEP: Inferred from expression pattern
9221949 RGD
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
23368426 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
8584038 RGD
involved in positive regulation of behavioral fear response IMP
IMP: Inferred from mutant phenotype
23368426 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
10426412 RGD
involved in response to epinephrine IEP
IEP: Inferred from expression pattern
8784263 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12503826 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
9581644 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20184566 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
22200548 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
15300902 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
8784263 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
25086310 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
23410195 RGD
involved in synaptic signaling via neuropeptide EXP
EXP: Inferred from Experiment
355888 RGD
involved in synaptic signaling via neuropeptide IMP
IMP: Inferred from mutant phenotype
355888 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23912034 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
20686827 RGD
located in cell body fiber IDA
IDA: Inferred from direct assay
20686827 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20686827 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
2695900 RGD
is active in neuronal dense core vesicle lumen IDA
IDA: Inferred from direct assay
8847409 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
23912034 RGD
located in symmetric synapse IDA
IDA: Inferred from direct assay
20686827 RGD
is active in synaptic vesicle lumen IDA
IDA: Inferred from direct assay
8847409 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proenkephalin-A

  • enkephalin

  • preproenkephalin 2

  • proenkephalin 1

  • proenkephalin 2

  • proenkephalin related sequence

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19363 Penk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10326 PENK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25855 Penk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Penk NCBI NCBI:5179