Por - cytochrome p450 oxidoreductase Gene

Also Known as CYPOR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29441

Summary

Enables several functions, including iron-cytochrome-c reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in several processes, including cellular response to hormone stimulus; negative regulation of hydrolase activity; and positive regulation of steroid biosynthetic process. Located in membrane and mitochondrion. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and Cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (Cytochrome P450 oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]

Por Products (1)

mRNA Protein Name
NM_031576.2 NP_113764.1 NADPH--cytochrome P450 reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables FMN binding IMP
IMP: Inferred from mutant phenotype
16928691 RGD
enables NADP binding IDA
IDA: Inferred from direct assay
9774150 RGD
enables NADP binding IMP
IMP: Inferred from mutant phenotype
16928691 RGD
enables NADPH-hemoprotein reductase activity IDA
IDA: Inferred from direct assay
9774150 RGD
enables NADPH-hemoprotein reductase activity IMP
IMP: Inferred from mutant phenotype
16928691 RGD
enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
IDA: Inferred from direct assay
16055078 RGD
enables electron transfer activity IDA
IDA: Inferred from direct assay
19171935 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
9774150 RGD
enables enzyme binding IMP
IMP: Inferred from mutant phenotype
16928691 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
11350928 RGD
enables flavin adenine dinucleotide binding IMP
IMP: Inferred from mutant phenotype
16928691 RGD
enables hydrolase activity IDA
IDA: Inferred from direct assay
16226717 RGD
enables iron-cytochrome-c reductase activity IDA
IDA: Inferred from direct assay
15823091 RGD
enables nitric oxide dioxygenase NAD(P)H activity IDA
IDA: Inferred from direct assay
19152507 RGD
Biological Process GO Annotation Evidence References Source
involved in carnitine metabolic process IEP
IEP: Inferred from expression pattern
16616465 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
19077323 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
19077323 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
19077323 RGD
involved in demethylation IDA
IDA: Inferred from direct assay
19171935 RGD
involved in fatty acid oxidation IDA
IDA: Inferred from direct assay
17400174 RGD
involved in flavonoid metabolic process IEP
IEP: Inferred from expression pattern
18803703 RGD
involved in internal peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
18194664 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in negative regulation of lipase activity IDA
IDA: Inferred from direct assay
18801337 RGD
involved in nitrate catabolic process IDA
IDA: Inferred from direct assay
16527817 RGD
involved in nitric oxide catabolic process IDA
IDA: Inferred from direct assay
19152507 RGD
involved in nitric oxide catabolic process IMP
IMP: Inferred from mutant phenotype
19152507 RGD
involved in positive regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in positive regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in positive regulation of steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
2495435 RGD
involved in regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in regulation of growth plate cartilage chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
19264869 RGD
involved in response to dexamethasone IDA
IDA: Inferred from direct assay
27856527 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17392395 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19265259 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADPH--cytochrome P450 reductase

  • CPR

  • P450 (cytochrome) oxidoreductase

  • P450R

  • cytochrome P450 reductase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0083 Ornipressin Agonist 99.68% Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15630 VDAC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P0083A Ornipressin acetate Agonist 99.63% Unkown
HY-RS10880 POR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17068 Por Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23512 Por Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Por NCBI NCBI:5447