P2ry2 - purinergic receptor P2Y2 Gene

Also Known as P2Y2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29597

About P2ry2

Primary_assembly 1: 155,351,165-155,367,632 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 201 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Liver (RPKM 266.1), Muscle (RPKM 112.6) and 7 other tissues.

Summary

Enables A1 Adenosine Receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with early endosome; lysosome; and mitochondrion. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]

P2ry2 Products (1)

mRNA Protein Name
NM_017255.2 NP_058951.2 P2Y purinoceptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables A1 adenosine receptor binding IPI
IPI: Inferred from physical interaction
11390975 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
11557527 RGD
enables G protein-coupled UTP receptor activity IDA
IDA: Inferred from direct assay
15924261 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11390975 RGD
Biological Process GO Annotation Evidence References Source
involved in blood vessel diameter maintenance IDA
IDA: Inferred from direct assay
12730558 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
19317852 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18689605 RGD
involved in cellular response to purine-containing compound IEP
IEP: Inferred from expression pattern
16831297 RGD
involved in in utero embryonic development IEP
IEP: Inferred from expression pattern
14517997 RGD
NOT involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
11245682 RGD
involved in negative regulation of ossification IDA
IDA: Inferred from direct assay
12210747 RGD
involved in positive regulation of chemokine production IDA
IDA: Inferred from direct assay
17947675 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
19155635 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
15379893 RGD
involved in positive regulation of penile erection IDA
IDA: Inferred from direct assay
19303093 RGD
involved in positive regulation of prostaglandin secretion IDA
IDA: Inferred from direct assay
15840771 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
11934835 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: Inferred from expression pattern
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
16000618 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
14714568 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
located in early endosome IDA
IDA: Inferred from direct assay
15924261 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16000618 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16000618 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
16000618 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry2 Protein Structure

7tmA_P2Y2

7tmA_P2Y2: cd15373 (33 - 315)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (33 - 60)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (67 - 92)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (105 - 135)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (147 - 169)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (194 - 223)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (236 - 266)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 2

  • ATP receptor

  • P2U purinoceptor 1

  • P2U1

  • P2Y ATP receptor 2

  • purinergic receptor P2Y, G-protein coupled, 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09928 P2RY2 Human Pre-designed siRNA Set A / Unkown
HY-RS09929 P2ry2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09930 P2ry2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2ry2 NCBI NCBI:5029