Atp2b1 - ATPase plasma membrane Ca2+ transporting 1 Gene

Also Known as Pmca1a; Pmca1b; Pmca1c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29598

Summary

Enables PDZ domain binding activity. Involved in several processes, including calcium ion export; cellular response to lipid; and response to cold. Located in several cellular components, including basolateral plasma membrane; dendritic spine membrane; and neuronal cell body membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Biomarker of hypertension. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b1 Products (3)

mRNA Protein Name
NM_001399339.1 NP_001386268.1 plasma membrane calcium-transporting ATPase 1 isoform 2
NM_001399343.1 NP_001386272.1 plasma membrane calcium-transporting ATPase 1 isoform 1
NM_053311.3 NP_445763.1 plasma membrane calcium-transporting ATPase 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16554037 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion export IMP
IMP: Inferred from mutant phenotype
9227424 RGD
involved in cellular response to corticosterone stimulus IEP
IEP: Inferred from expression pattern
10777776 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
11277270 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
16079002 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in apical part of cell IDA
IDA: Inferred from direct assay
18395836 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18395836 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16803870 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20575074 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
20575074 RGD
located in dendritic spine membrane IDA
IDA: Inferred from direct assay
20575074 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
20575074 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma membrane calcium-transporting ATPase 1

  • ATPase, Ca++ transporting, plasma membrane 1

  • PMCA1

  • plasma membrane calcium ATPase

  • plasma membrane calcium pump

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01194 ATP2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20524 Atp2b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27033 Atp2b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2b1 NCBI NCBI:490