Scn1b - sodium voltage-gated channel beta subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29686

Summary

Enables Sodium Channel regulator activity. Involved in regulation of voltage-gated Sodium Channel activity and response to pyrethroid. Is integral component of plasma membrane. Part of voltage-gated Sodium Channel complex. Colocalizes with node of Ranvier. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Scn1b Products (3)

mRNA Protein Name
NM_001271045.2 NP_001257974.1 sodium channel subunit beta-1 isoform 1 precursor
NM_001271046.2 NP_001257975.1 sodium channel subunit beta-1 isoform 2
NM_017288.3 NP_058984.1 sodium channel subunit beta-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10737807 RGD
enables sodium channel regulator activity IDA
IDA: Inferred from direct assay
17517192 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
1375395 RGD
involved in regulation of voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
28012039 RGD
involved in response to pyrethroid IDA
IDA: Inferred from direct assay
19026681 RGD
Cellular Component GO Annotation Evidence References Source
located in node of Ranvier IDA
IDA: Inferred from direct assay
11470829 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11470829 RGD
part of voltage-gated sodium channel complex IDA
IDA: Inferred from direct assay
1375395 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium channel subunit beta-1

  • sodium channel, voltage-gated, type 1, beta polypeptide

  • sodium channel, voltage-gated, type I, beta polypeptide

  • sodium channel, voltage-gated, type I, beta subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12528 SCN1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22797 Scn1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29311 Scn1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn1b NCBI NCBI:6324