Gabra5 - gamma-aminobutyric acid type A receptor subunit alpha 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29707

Summary

Enables GABA Receptor binding activity; GABA-A receptor activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in brain development and chemical synaptic transmission. Located in dendrite and neuronal cell body membrane. Part of receptor complex. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]

Gabra5 Products (1)

mRNA Protein Name
NM_017295.2 NP_058991.2 gamma-aminobutyric acid receptor subunit alpha-5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GABA receptor binding IPI
IPI: Inferred from physical interaction
17959749 RGD
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
2153588 RGD
enables GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
10462548 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
17951598 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
17951598 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IEP
IEP: Inferred from expression pattern
15246695 RGD
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
2153588 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
17951598 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
16998906 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15246695 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
15246695 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16998906 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
16998906 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16998906 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
17959749 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-5

  • GABA(A) receptor subunit alpha-5

  • GABA-A receptor alpha-5 subunit

  • gamma-aminobutyric acid (GABA) A receptor, alpha 5

  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5

  • gamma-aminobutyric acid A receptor, alpha 5

  • gamma-aminobutyric acid type A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05213 GABRA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186006 GABRA5 modulator-1 / Unkown
HY-RS21856 Gabra5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28373 Gabra5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra5 NCBI NCBI:2558