Slc4a8 - solute carrier family 4 member 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315311

Summary

Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; inorganic ion transmembrane transport; and regulation of intracellular pH. Predicted to act upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of membrane potential. Located in several cellular components, including axon; glutamatergic synapse; and synaptic vesicle. Biomarker of prediabetes syndrome. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a8 Products (3)

mRNA Protein Name
NM_001270794.1 NP_001257723.1 electroneutral sodium bicarbonate exchanger 1 isoform 2
NM_001270795.1 NP_001257724.1 electroneutral sodium bicarbonate exchanger 1 isoform 3
NM_199497.2 NP_955791.1 electroneutral sodium bicarbonate exchanger 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
34584093 RGD
enables sodium,bicarbonate:chloride antiporter activity IDA
IDA: Inferred from direct assay
8189393 RGD
enables sodium,bicarbonate:chloride antiporter activity IMP
IMP: Inferred from mutant phenotype
34584093 RGD
Biological Process GO Annotation Evidence References Source
involved in basolateral protein secretion IDA
IDA: Inferred from direct assay
21195699 RGD
involved in regulation of intracellular pH IDA
IDA: Inferred from direct assay
8189393 RGD
Cellular Component GO Annotation Evidence References Source
located in asymmetric synapse IDA
IDA: Inferred from direct assay
22102085 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
22102085 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18359573 RGD
located in glial cell projection IDA
IDA: Inferred from direct assay
22102085 RGD
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
22102085 RGD
located in hippocampal mossy fiber IDA
IDA: Inferred from direct assay
22102085 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
22102085 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17715183 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
34584093 RGD
located in presynapse IDA
IDA: Inferred from direct assay
22102085 RGD
located in symmetric synapse IDA
IDA: Inferred from direct assay
22102085 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
22102085 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
22102085 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
22102085 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electroneutral sodium bicarbonate exchanger 1

  • Na-driven Cl-HCO3 exchanger NDCBE1-A

  • Na-driven Cl-HCO3 exchanger NDCBE1-B

  • Na-driven Cl-HCO3 exchanger NDCBE1-C

  • electroneutral Na+-driven Cl-HCO3 exchanger

  • k-NBC3

  • solute carrier family 4 (anion exchanger), member 8

  • solute carrier family 4, sodium bic

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13273 SLC4A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21937 Slc4a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28453 Slc4a8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a8 NCBI NCBI:9498