Lefty2 - left-right determination factor 2 Gene
Also Known as Ebaf; Lefta; Leftb; lefty-2; lefty-B; 6030463A22Rik
Species: Mus musculus
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]
Lefty2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_177099.4 | NP_796073.1 | left-right determination factor 2 preproprotein |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
left-right determination factor 2 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS07586 | LEFTY2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18868 | Lefty2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS25359 | Lefty2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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