Myo3b - myosin IIIB Gene

Also Known as A430065P19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 329421

Summary

Enables microfilament motor activity and protein serine/threonine kinase activity. Involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Acts upstream of or within positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Is active in stereocilium tip. Is expressed in several structures, including genitourinary system; nervous system; and submandibular gland. Orthologous to human MYO3B (Myosin IIIB). [provided by Alliance of Genome Resources, Apr 2022]

Myo3b Products (1)

mRNA	Protein	Name
NM_177376.5	NP_796350.2	myosin-IIIb

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microfilament motor activity	IDA IDA: Inferred from direct assay	22264607	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22264607	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21895655	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in auditory receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	26754646	MGI
involved in auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	26754646	MGI
involved in cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	26754646	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
acts upstream of or within positive regulation of filopodium assembly	IPI IPI: Inferred from physical interaction	22264607	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	21895655	MGI
involved in regulation of actin filament length	IGI IGI: Inferred from genetic interaction	26754646	MGI
involved in regulation of actin filament length	IMP IMP: Inferred from mutant phenotype	26754646	MGI
involved in sensory perception of sound	IGI IGI: Inferred from genetic interaction	26754646	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	26754646	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in filopodium tip	IPI IPI: Inferred from physical interaction	22264607	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	19332056	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	19332056	MGI
is active in stereocilium tip	EXP EXP: Inferred from Experiment	26754646	MGI
located in stereocilium tip	IDA IDA: Inferred from direct assay	22264607	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myosin-IIIb	myosin IIIB1 myosin IIIB2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08945	MYO3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22664	Myo3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29178	Myo3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo3b	NCBI	NCBI:140469