country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Nlrp1a - NLR family, pyrin domain containing 1A Gene

Also Known as Nalp1; Nlrp1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 360557

About Nlrp1a

Primary_assembly 10: 55,778,560-55,825,180 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 87 orthologues, 21 paralogues and is associated with 5 phenotypes. Biased expression in Thymus (RPKM 161.4), Spleen (RPKM 147.) and 8 other tissues.

Summary

Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of Pyroptosis. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a Products (1)

mRNA	Protein	Name
NM_001145755.2	NP_001139227.2	NACHT, LRR and PYD domains-containing protein 1a allele 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cellular defense response	IMP IMP: Inferred from mutant phenotype	24626226	RGD
involved in positive regulation of pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	24626226	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	19401709	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19416975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nlrp1a Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

FIIND

CARD_ASC_NALP1

0
200
400
600
800
1000
1218 a.a.

Protein Preferred Names	Protein Names
NACHT, LRR and PYD domains-containing protein 1a allele 1 NACHT, LRR and PYD domains-containing protein 1	NACHT, LRR and PYD domains-containing protein 1a NACHT, leucine rich repeat and PYD containing 1 NLR family protein 1 NLR family, pyrin domain containing 1 resistant anthrax lethal toxin

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 1a allele 1

NACHT, LRR and PYD domains-containing protein 1

NACHT, LRR and PYD domains-containing protein 1a
NACHT, leucine rich repeat and PYD containing 1
NLR family protein 1
NLR family, pyrin domain containing 1
resistant anthrax lethal toxin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09354	Nlrp1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09355	Nlrp1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown