Nlrp1a - NLR family, pyrin domain containing 1A Gene

Rattus norvegicus

Also known as Nalp1; Nlrp1

Gene ID: 360557 | Gene type: protein coding

About Nlrp1a

Primary_assembly 10: 55,778,560-55,825,180 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 87 orthologues, 21 paralogues and is associated with 5 phenotypes. Biased expression in Thymus (RPKM 161.4), Spleen (RPKM 147.) and 8 other tissues.

Summary

Enables scaffold protein binding activity. Involved in negative regulation of cellular defense response and positive regulation of Pyroptosis. Located in neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp1a Products(1)

mRNA	Protein	Name
NM_001145755.2	NP_001139227.2	NACHT, LRR and PYD domains-containing protein 1a allele 1

Nlrp1a Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

FIIND

CARD_ASC_NALP1

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1218 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 1a allele 1

NACHT, LRR and PYD domains-containing protein 1

NACHT, LRR and PYD domains-containing protein 1a	NACHT, leucine rich repeat and PYD containing 1
NLR family protein 1	NLR family, pyrin domain containing 1
resistant anthrax lethal toxin

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09354	Nlrp1a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09355	Nlrp1a Rat Pre-designed siRNA Set A		/	Unkown

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