NOSIP - nitric oxide synthase interacting protein Gene

Also Known as CGI-25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51070

About NOSIP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,555,468-49,580,556 (from NCBI)

This gene has 16 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in testis (RPKM 21.1), lymph node (RPKM 12.2) and 25 other tissues.

Summary

The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

NOSIP Products (3)

mRNA Protein Name
NM_001270960.2 NP_001257889.1 nitric oxide synthase-interacting protein isoform 1
NM_001363649.2 NP_001350578.1 nitric oxide synthase-interacting protein isoform 2
NM_015953.5 NP_057037.1 nitric oxide synthase-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular sequestering activity IPI
IPI: Inferred from physical interaction
15548660 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11149895 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
11149895 GOA
involved in negative regulation of nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
11149895 GOA
involved in regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
15548660 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15548660 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15548660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nitric oxide synthase-interacting protein

  • E3 ubiquitin-protein ligase NOSIP

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 3

  • Congenital Generalized Lipodystrophy Type 3

  • CGL3

  • Bscl3

  • Berardinelli-Seip Congenital Lipodystrophy Type 3

  • Berardinelli-Seip Congenital Lipodystrophy, Type 3

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 3

  • Type 3 Berardinelli-Seip Congenital Lipodystrophy

  • Congenital Generalized Lipodystrophy 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09443 NOSIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NOSIP MGD MGI:1913644
Macaca mulatta NOSIP VGNC VGNC:75207
Canis familiaris NOSIP VGNC VGNC:53744
Rattus norvegicus NOSIP RGD RGD:1309992
Bos taurus NOSIP VGNC VGNC:32175
Felis catus NOSIP VGNC VGNC:63861
Others NOSIP NCBI