Hnrnpu - heterogeneous nuclear ribonucleoprotein U Gene

Also Known as SAFA; Hnrpu; Sp120; hnRNP U

Species: Mus musculus

Gene Type: protein coding
Gene ID: 51810

Summary

Enables RNA polymerase II C-terminal domain binding activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including RNA localization to chromatin; cellular response to leukemia inhibitory factor; and regulation of gene expression. Acts upstream of or within with a positive effect on mRNA metabolic process. Acts upstream of or within cardiac muscle cell development. Located in inactive sex chromosome and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; future brain; limb primordium; tail bud; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpu Products (1)

mRNA Protein Name
NM_016805.3 NP_058085.2 heterogeneous nuclear ribonucleoprotein U

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
20833368 MGI
enables RNA binding IPI
IPI: Inferred from physical interaction
25921091 MGI
enables RNA polymerase II C-terminal domain binding IDA
IDA: Inferred from direct assay
21235343 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18332112 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
25921091 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
21235343 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18495661 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21235343 MGI
Biological Process GO Annotation Evidence References Source
involved in RNA localization to chromatin IMP
IMP: Inferred from mutant phenotype
20833368 MGI
involved in adaptive thermogenesis IMP
IMP: Inferred from mutant phenotype
28784777 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
26039991 MGI
involved in cellular response to leukemia inhibitory factor IDA
IDA: Inferred from direct assay
21235343 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
18332112 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IDA
IDA: Inferred from direct assay
15312650 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IMP
IMP: Inferred from mutant phenotype
15312650 MGI
involved in dosage compensation by inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
20833368 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
28636939 MGI
acts upstream of or within positive effect mRNA metabolic process IMP
IMP: Inferred from mutant phenotype
25921091 MGI
involved in negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
21235343 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
28784777 MGI
involved in positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20833368 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22162999 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21235343 MGI
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
25915022 MGI
Cellular Component GO Annotation Evidence References Source
located in inactive sex chromosome IDA
IDA: Inferred from direct assay
20833368 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18332112 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
25921091 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein U

  • heterogenous nuclear ribonucleoprotein U

  • nuclear matrix protein sp120

  • scaffold attachment factor A

Hnrnpu Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hnrnpu Q8VEK3 Smarca4 Mus musculus Q3TKT4
PLA
22162999
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06278 HNRNPU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21138 Hnrnpu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27656 Hnrnpu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnrnpu NCBI NCBI:3192