Snx3 - sorting nexin 3 Gene

Also Known as SDP3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54198

Summary

Enables phosphatidylinositol phosphate binding activity. Involved in positive regulation of neuron projection development. Acts upstream of or within several processes, including Hemoglobin biosynthetic process; regulation of intracellular protein transport; and transferrin transport. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic microphthalmia 8. Orthologous to human SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Apr 2022]

Snx3 Products (2)

mRNA Protein Name
NM_017472.4 NP_059500.2 sorting nexin-3
NM_017472.4 NP_059500.2 sorting nexin-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
19576982 MGI
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
19576982 MGI
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
19576982 MGI
enables phosphatidylinositol-5-phosphate binding IDA
IDA: Inferred from direct assay
19576982 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23416069 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hemoglobin biosynthetic process IMP
IMP: Inferred from mutant phenotype
23416069 MGI
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
19576982 MGI
acts upstream of or within regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
23416069 MGI
acts upstream of or within regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
23416069 MGI
acts upstream of or within transferrin transport IMP
IMP: Inferred from mutant phenotype
23416069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sorting nexin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181439 SNX3-IN-1 Inhibitor / Unkown
HY-RS13539 SNX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snx3 NCBI NCBI:8724