Arhgef5 - Rho guanine nucleotide exchange factor (GEF) 5 Gene

Also Known as Tim1; 2210412D05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54324

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid dendritic cell chemotaxis; and positive regulation of podosome assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef5 Products (1)

mRNA Protein Name
NM_133674.1 NP_598435.1 rho guanine nucleotide exchange factor 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21525037 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
21525037 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
26880577 MGI
acts upstream of or within myeloid dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
19713215 MGI
acts upstream of or within positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
21525037 MGI
acts upstream of or within positive regulation of podosome assembly IGI
IGI: Inferred from genetic interaction
21525037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00962 ARHGEF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef5 NCBI NCBI:7984