CRLS1 - cardiolipin synthase 1 Gene

Also Known as CLS; CLS1; GCD10; C20orf155; dJ967N21.6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54675

About CRLS1

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:6,005,938-6,040,053 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 13.5), lung (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]

CRLS1 Products (6)

mRNA Protein Name
NM_001127458.2 NP_001120930.1 cardiolipin synthase (CMP-forming) isoform 2
NM_001323561.2 NP_001310490.1 cardiolipin synthase (CMP-forming) isoform 3
NM_001323562.2 NP_001310491.1 cardiolipin synthase (CMP-forming) isoform 3
NM_001323563.2 NP_001310492.1 cardiolipin synthase (CMP-forming) isoform 3
NM_001323564.2 NP_001310493.1 cardiolipin synthase (CMP-forming) isoform 3
NM_019095.6 NP_061968.1 cardiolipin synthase (CMP-forming) isoform 1

CRLS1 Protein Structure

CDP-OH_P_transf

CDP-OH_P_transf: CDP-alcohol phosphatidyltransferase (107 - 203)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

cardiolipin synthase (CMP-forming)

Related Diseases

Diseases Alias
Barth Syndrome

  • 3-Methylglutaconic Aciduria Type 2

  • BTHS

  • Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

  • Mga Type Ii

  • Mga2

  • Mgca2

  • Mga Type 2

  • 3-Methylglutaconic Aciduria Type Ii

  • 3-Methylglutaconic Aciduria, Type Ii

  • Mga, Type Ii

  • 3-Methylglutaconicaciduria Type 2

  • 3-Methylglutaconicaciduria Type Ii

  • Taz Defect

  • 3 Methylglutaconic Aciduria, Type Ii

  • Dnajc19 Defect

  • Cardioskeletal Myopathy-Neutropenia Syndrome

  • X-Linked Cardioskeletal Myopathy And Neutropenia

  • 3-Alpha-Methylglutaconic Aciduria Type 2

  • Agm2

  • Cardioskeletal Myopathy-Neutropenia

  • Invm

  • Left Ventricular Non-Compaction Isolated X-Linked

  • Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

  • Agammaglobulinemia 2, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03189 CRLS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175756 SMARCA2/4 degrader-1 Degrader / Unkown
HY-RS20895 Crls1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27412 Crls1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CRLS1 VGNC VGNC:27719
Macaca mulatta CRLS1 VGNC VGNC:71419
Rattus norvegicus CRLS1 RGD RGD:1311037
Canis familiaris CRLS1 VGNC VGNC:39623
Mus musculus CRLS1 MGD MGI:1913836
Felis catus CRLS1 VGNC VGNC:61185
Others CRLS1 NCBI