2. Gene
  3. Letm1 - leucine zipper-EF-hand containing transmembrane protein 1 Gene

Letm1 - leucine zipper-EF-hand containing transmembrane protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 56384 | Gene type: protein coding

About Letm1

Summary

Enables calcium:proton antiporter activity. Involved in cellular calcium ion homeostasis and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in gonad and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Letm1 Products(1)

mRNA Protein Name
NM_019694.2 NP_062668.1 mitochondrial proton/calcium exchanger protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium:proton antiporter activity IDA
IDA: Inferred from direct assay
27669901 MGI
enables calcium:proton antiporter activity IMP
IMP: Inferred from mutant phenotype
23716663 MGI
Biological Process GO Annotation Evidence Reference Source
involved in calcium export from the mitochondrion IDA
IDA: Inferred from direct assay
27669901 MGI
involved in calcium export from the mitochondrion IMP
IMP: Inferred from mutant phenotype
23716663 MGI
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
27669901 MGI
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
27669901 MGI
involved in protein hexamerization IDA
IDA: Inferred from direct assay
27669901 MGI
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
27669901 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27669901 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14651853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial proton/calcium exchanger protein

LETM1 and EF-hand domain-containing protein 1, mitochondrial

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07597 LETM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Letm1 NCBI NCBI:3954