GRAMD1A - GRAM domain containing 1A Gene

Also Known as KIAA1533

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57655

About GRAMD1A

This gene has 15 transcripts (splice variants), 191 orthologues and 4 paralogues. Ubiquitous expression in lung (RPKM 13.7), spleen (RPKM 13.3) and 25 other tissues.

Summary

Predicted to enable Cholesterol binding activity and Cholesterol transfer activity. Predicted to be involved in cellular response to Cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

GRAMD1A Products (5)

mRNA Protein Name
NM_001136199.3 NP_001129671.1 protein Aster-A isoform 2
NM_001320034.2 NP_001306963.1 protein Aster-A isoform 3
NM_001320035.2 NP_001306964.1 protein Aster-A isoform 4
NM_001320036.2 NP_001306965.1 protein Aster-A isoform 5
NM_020895.5 NP_065946.2 protein Aster-A isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
29469807 GOA
located in organelle membrane contact site IDA
IDA: Inferred from direct assay
29469807 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
29469807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAMD1A Protein Structure

GRAM

GRAM: GRAM domain (91 - 157)

  • 0
  • 200
  • 400
  • 600
  • 724 a.a.
Protein Preferred Names Protein Names

protein Aster-A

  • GRAM domain-containing protein 1A

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05772 GRAMD1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GRAMD1A VGNC VGNC:73029
Canis familiaris GRAMD1A VGNC VGNC:41465
Bos taurus GRAMD1A VGNC VGNC:29622
Mus musculus GRAMD1A MGD MGI:105490
Rattus norvegicus GRAMD1A RGD RGD:1311022
Felis catus GRAMD1A VGNC VGNC:62701
Others GRAMD1A NCBI