ARHGEF28 - Rho guanine nucleotide exchange factor 28 Gene

Also Known as RIP2; RGNEF; p190RHOGEF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64283

About ARHGEF28

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,626,196-73,941,990 (from NCBI)

This gene has 14 transcripts (splice variants), 277 orthologues and 8 paralogues. Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 21 other tissues.

Summary

This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

ARHGEF28 Products (5)

mRNA	Protein	Name
NM_001080479.3	NP_001073948.2	rho guanine nucleotide exchange factor 28 isoform 1
NM_001177693.2	NP_001171164.1	rho guanine nucleotide exchange factor 28 isoform 2
NM_001244364.2	NP_001231293.1	rho guanine nucleotide exchange factor 28 isoform 3
NM_001388076.1	NP_001375005.1	rho guanine nucleotide exchange factor 28 isoform 4
NM_001388078.1	NP_001375007.1	rho guanine nucleotide exchange factor 28 isoform 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	11058585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF28 Protein Structure

C1_1

RhoGEF

0
300
600
900
1200
1500
1705 a.a.

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor 28	190 kDa guanine nucleotide exchange factor

Related Diseases

Diseases	Alias
Cri-Du-Chat Syndrome	5p Deletion Syndrome 5p Partial Monosomy Syndrome Monosomy 5p Cat Cry Syndrome Chromosome 5p Deletion Syndrome Cri Du Chat Syndrome 5p- Syndrome 5p Minus Syndrome Chromosome 5p- Syndrome Chromosome 5 Short Arm Deletion Syndrome Chromosome 5p Deletion Deletion 5p Cri Du Chat 5p Partial Deletion Syndrome Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00957	ARHGEF28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF28	VGNC	VGNC:38083
Felis catus	ARHGEF28	VGNC	VGNC:59905
Mus musculus	ARHGEF28	MGD	MGI:1346016
Bos taurus	ARHGEF28	VGNC	VGNC:26114
Macaca mulatta	ARHGEF28	VGNC	VGNC:84279
Rattus norvegicus	ARHGEF28	RGD	RGD:1307061
Others	ARHGEF28	NCBI