ARHGEF28 - Rho guanine nucleotide exchange factor 28 Gene

Homo sapiens

Also known as RIP2; RGNEF; p190RHOGEF

Gene ID: 64283 | Gene type: protein coding

About ARHGEF28

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,626,196-73,941,990 (from NCBI)

This gene has 14 transcripts (splice variants), 277 orthologues and 8 paralogues. Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 21 other tissues.

Summary

This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

ARHGEF28 Products(5)

mRNA	Protein	Name
NM_001080479.3	NP_001073948.2	rho guanine nucleotide exchange factor 28 isoform 1
NM_001177693.2	NP_001171164.1	rho guanine nucleotide exchange factor 28 isoform 2
NM_001244364.2	NP_001231293.1	rho guanine nucleotide exchange factor 28 isoform 3
NM_001388076.1	NP_001375005.1	rho guanine nucleotide exchange factor 28 isoform 4
NM_001388078.1	NP_001375007.1	rho guanine nucleotide exchange factor 28 isoform 5

ARHGEF28 Protein Structure

C1_1

RhoGEF

0
300
600
900
1200
1500
1705 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 28

190 kDa guanine nucleotide exchange factor

Related Diseases

Diseases

Alias

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00957	ARHGEF28 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF28	VGNC	VGNC:38083
Felis catus	ARHGEF28	VGNC	VGNC:59905
Mus musculus	ARHGEF28	MGD	MGI:1346016
Bos taurus	ARHGEF28	VGNC	VGNC:26114
Macaca mulatta	ARHGEF28	VGNC	VGNC:84279
Rattus norvegicus	ARHGEF28	RGD	RGD:1307061

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