BLVRA - biliverdin reductase A Gene

Also Known as BVR; BLVR; BVRA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 644

About BLVRA

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:43,758,122-43,807,342 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 33.2), lung (RPKM 23.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

BLVRA Products (2)

mRNA Protein Name
NM_000712.4 NP_000703.2 biliverdin reductase A
NM_001253823.2 NP_001240752.1 biliverdin reductase A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables biliberdin reductase (NAD+) activity IDA
IDA: Inferred from direct assay
7929092 GOA
enables biliverdin reductase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
7929092 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18463290 GOA
Biological Process GO Annotation Evidence References Source
involved in heme catabolic process IDA
IDA: Inferred from direct assay
10858451 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
7929092 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLVRA Protein Structure

GFO_IDH_MocA

GFO_IDH_MocA: Oxidoreductase family, NAD-binding Rossmann fold (9 - 124)

Biliv-reduc_cat

Biliv-reduc_cat: Biliverdin reductase, catalytic (132 - 245)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

biliverdin reductase A

  • BVR A

BLVRA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BLVRA P53004 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
BLVRA P53004 LNX1 Homo sapiens Q8TBB1
Y2H Array
31515488
Intra
BLVRA P53004 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
BLVRA P53004 MAPK1 Homo sapiens P28482
Anti Bait CoIP
18463290
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BLVRA Proteins

Cat. No. Product Name Accession Purity
HY-P7664 Biliverdin Reductase A/BLVRA Protein, Human (C-His) P53004 (E6-S294) ≥ 95%, as determined by reducing SDS-PAGE.

BLVRA Antibodies

Cat. No. Product Name Application Reactivity
HY-P811292 BLVRA Antibody WB, IHC-P Human, Mouse
HY-P89730 BLVRA Antibody (YA9074) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Hyperbiliverdinemia

  • Green Jaundice

  • HBLVD
Cholestasis

  • Obstruction Of Bile Duct

  • Bile Duct Obstruction

  • Bile Occlusion

  • Extrahepatic Biliary Obstruction

  • Extrahepatic Bile Duct Obstruction

  • Bile Stasis

  • Biliary Stasis

  • Obstructive Hyperbilirubinemia

  • Obstructed Jaundice

  • Bile Duct Obstructed

  • Bile Ductal Obstruction

  • Biliary Duct Obstruction

  • Obstructed Bile Ductal

  • Obstructed Biliary Duct

  • Obstructed Biliary Ductal

  • Jaundice Regurgitation

  • Obstructive Jaundice

  • Cholestatic Jaundice

  • Cholestatic Jaundice Syndrome
Pneumothorax

  • Pneumothorax Nos

  • Air Leak Nos

  • Pleural Air Leak Nos
Kernicterus

  • Bilirubin Encephalopathy

  • Hyperbilirubinemic Encephalopathy

  • Kernicterus Spectrum Disorder
Gilbert Syndrome

  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia
Acute Contagious Conjunctivitis

  • Pink Eye

  • Contagious Opthalmia

  • Pinkeye

  • Conjunctivitis

  • Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Acute Conjunctivitis
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Crigler-Najjar Syndrome, Type I

  • Crigler-Najjar Syndrome

  • Crigler-Najjar Syndrome Type 1

  • Bilirubin Udp Glucuronyl Transferase Deficiency

  • Crigler Najjar Syndrome

  • Crigler Najjar Syndrome, Type 1

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

  • Bilirubin-Ugt Deficiency

  • Hyperbilirubinemia, Crigler-Najjar Type I

  • Hblrcn1

  • Familial Nonhemolytic Unconjugated Hyperbilirubinemia

  • Hereditary Unconjugated Hyperbilirubinemia

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

  • Bilirubin-Ugt Deficiency Type 1

  • Crigler-Najjar Syndrome 1

  • CN1

  • Cn-I

  • Crigler-Najjar Syndrome Type I

  • Hereditary Unconjugated Hyperbilirubinaemia

  • Ugt Deficiency

  • Bilirubin Glucuronosyltransferase Deficiency

  • Crigler-Najjar Disease Or Syndrome

  • Deficiency Of Glucuronosyltransferase

  • Glucuronyl Transferase Deficiency

  • Glucuronyltransferase Deficiency

  • Udp Glucuronyl Transferase Deficiency

  • Cns - [Crigler-Najjar Syndrome]

  • Congenital Familial Nonhemolytic Jaundice
Intracranial Berry Aneurysm

  • Familial Aneurysmal Subarachnoid Hemorrhage

  • Familial Berry Aneurysm

  • Familial Intracranial Saccular Aneurysm

  • Saccular Cerebral Aneurysm

  • Aneurysm, Intracranial Berry

  • Aneurysmal Subarachnoid Hemorrhage

  • Aneurysm, Intracranial Berry, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01526 BLVRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19658 Blvra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26151 Blvra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BLVRA RGD RGD:620721
Canis familiaris BLVRA VGNC VGNC:38471
Macaca mulatta BLVRA VGNC VGNC:70256
Bos taurus BLVRA VGNC VGNC:26510
Mus musculus BLVRA MGD MGI:88170
Others BLVRA NCBI