BLVRA Antibody
(Synonyms: BLVR, BVR, BLVRA, Biliverdin reductase A, BVR A, Biliverdin-IX alpha-reductase)BLVRA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BLVRA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
BLVRA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BLVRA.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 38 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 33 kDa
Purified recombinant protein of human BLVRA.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BLVRA reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems[1][2][3][4].
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Subcellular Localization
Cytoplasm, cytosol
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Expression
Tissue_Specificity: Liver. -
Isoforms & Post-Translational Modification
BLVRA has an amino acid length of 296, molecular weight is 33428 Da.
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Subunit
Monomer
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SwissProt ID
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Synonyms
BLVR, BVR, BLVRA, Biliverdin reductase A, BVR A, Biliverdin-IX alpha-reductase
Documentation
[1]. Cunningham O, et al. Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites. J Biol Chem. 2000 Jun 23;275(25):19009-17. [Content Brief]
[2]. Yamaguchi T, et al. Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization. J Biol Chem. 1994 Sep 30;269(39):24343-8. [Content Brief]
[3]. Maines MD, et al. Purification and characterization of human biliverdin reductase. Arch Biochem Biophys. 1993 Jan;300(1):320-6. [Content Brief]
[4]. Maines MD, et al. Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes. Eur J Biochem. 1996 Jan 15;235(1-2):372-81. [Content Brief]
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