2. Gene
  3. Bcl2l11 - Bcl2-like 11 Gene

Bcl2l11 - Bcl2-like 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bim; Bod; BimL

Gene ID: 64547 | Gene type: protein coding

About Bcl2l11

Primary_assembly 3: 115,366,646-115,404,068 forward strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 4 phenotypes. Biased expression in Thymus (RPKM 6.4), Spleen (RPKM 47.5) and 9 other tissues.

Summary

Predicted to enable dynein complex binding activity and protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of Autophagy in response to ER overload. Located in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 Products(1)

mRNA Protein Name
NM_171988.3 NP_741985.1 bcl-2-like protein 11

Bcl2l11 Protein Structure

Bim_N

Bim_N: pfam06773 (110 - 145)

Bclx_interact

Bclx_interact: pfam08945 (235 - 270)

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  • 303 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 11

BCL2-like 11 (apoptosis facilitator)

Bcl-2 related apoptotic gene product BimL

bcl-2-related ovarian death protein

bcl2-interacting mediator of cell death

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153953 Bcl-2-IN-11 Inhibitor / Unkown
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / Unkown
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l11 NCBI NCBI:10018