Bcl2l11 - Bcl2-like 11 Gene

Also Known as Bim; Bod; BimL

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64547

About Bcl2l11

Primary_assembly 3: 115,366,646-115,404,068 forward strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 4 phenotypes. Biased expression in Thymus (RPKM 6.4), Spleen (RPKM 47.5) and 9 other tissues.

Summary

Predicted to enable dynein complex binding activity and protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of Autophagy in response to ER overload. Located in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 Products (1)

mRNA Protein Name
NM_171988.3 NP_741985.1 bcl-2-like protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9731710 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
17287517 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17287517 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
12388545 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9731710 RGD
involved in positive regulation of autophagy in response to ER overload IMP
IMP: Inferred from mutant phenotype
25772147 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l11 Protein Structure

Bim_N

Bim_N: pfam06773 (110 - 145)

Bclx_interact

Bclx_interact: pfam08945 (235 - 270)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 11

  • BCL2-like 11 (apoptosis facilitator)

  • Bcl-2 related apoptotic gene product BimL

  • bcl-2-related ovarian death protein

  • bcl2-interacting mediator of cell death

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153953 Bcl-2-IN-11 Inhibitor / Unkown
HY-RS01427 BCL2L11 Human Pre-designed siRNA Set A / Unkown
HY-RS01428 Bcl2l11 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01429 Bcl2l11 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2l11 NCBI NCBI:10018