Tctn1 - tectonic family member 1 Gene

Also Known as Tect1; 4930565B19Rik; G730031O11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 654470

Summary

Involved in cilium assembly and protein localization to ciliary transition zone. Acts upstream of or within in utero embryonic development; nervous system development; and regulation of smoothened signaling pathway. Located in ciliary transition zone; extracellular space; and membrane. Part of MKS complex. Is expressed in several structures, including gut epithelium; neural tube; node; notochord; and somite. Human ortholog(s) of this gene implicated in Joubert syndrome 13. Orthologous to human TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Tctn1 Products (1)

mRNA	Protein	Name
NM_001039153.3	NP_001034242.2	tectonic-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21565611	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within central nervous system interneuron axonogenesis	IMP IMP: Inferred from mutant phenotype	16357211	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	21725307	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	16357211	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16357211	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	16357211	MGI
involved in protein localization to ciliary transition zone	IMP IMP: Inferred from mutant phenotype	26982032	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16357211	MGI
acts upstream of or within somatic motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	16357211	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	16357211	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of MKS complex	IDA IDA: Inferred from direct assay	21725307	MGI
located in ciliary transition zone	IMP IMP: Inferred from mutant phenotype	21725307	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	16357211	MGI
located in membrane	IDA IDA: Inferred from direct assay	22179047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tectonic-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14326	TCTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21782	Tctn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28299	Tctn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tctn1	NCBI	NCBI:79600