2. Gene
  3. Isx - intestine specific homeobox Gene

Isx - intestine specific homeobox Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pix-1; 9130012O13Rik

Gene ID: 71597 | Gene type: protein coding

About Isx

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of intestinal absorption; regulation of transcription by RNA polymerase II; and regulation of vitamin A metabolic process. Predicted to be located in nucleus. Is expressed in genitourinary system; midgut; and thymus. Orthologous to human ISX (intestine specific homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Isx Products(2)

mRNA Protein Name
NM_001294278.2 NP_001281207.1 intestine-specific homeobox isoform 1
NM_027837.4 NP_082113.2 intestine-specific homeobox isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25701869 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25701869 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of intestinal absorption IMP
IMP: Inferred from mutant phenotype
25701869 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18093975 MGI
acts upstream of or within regulation of vitamin A metabolic process IMP
IMP: Inferred from mutant phenotype
18093975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intestine-specific homeobox

pancreas-intestine homeodomain transcription factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12323 ISX-9 Activator 99.76% Unkown
HY-113790 ISX-1 Inhibitor 98.05% Unkown
HY-148694 ISX-3 Activator 99.68% Unkown
HY-12323G ISX-9 (GMP) Activator / Unkown
HY-RS06940 ISX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isx NCBI NCBI:91464