Isx - intestine specific homeobox Gene

Also Known as Pix-1; 9130012O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71597

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of intestinal absorption; regulation of transcription by RNA polymerase II; and regulation of vitamin A metabolic process. Predicted to be located in nucleus. Is expressed in genitourinary system; midgut; and thymus. Orthologous to human ISX (intestine specific homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Isx Products (2)

mRNA Protein Name
NM_001294278.2 NP_001281207.1 intestine-specific homeobox isoform 1
NM_027837.4 NP_082113.2 intestine-specific homeobox isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25701869 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25701869 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of intestinal absorption IMP
IMP: Inferred from mutant phenotype
25701869 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18093975 MGI
acts upstream of or within regulation of vitamin A metabolic process IMP
IMP: Inferred from mutant phenotype
18093975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intestine-specific homeobox

  • pancreas-intestine homeodomain transcription factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12323 ISX-9 Activator 99.76% Unkown
HY-113790 ISX-1 Inhibitor 98.05% Unkown
HY-148694 ISX-3 Activator 99.68% Unkown
HY-12323G ISX-9 (GMP) Activator / Unkown
HY-RS06940 ISX Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isx NCBI NCBI:91464