WNT10A - Wnt family member 10A Gene

Homo sapiens

Also known as OODD; SSPS; STHAG4

Gene ID: 80326 | Gene type: protein coding

About WNT10A

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,874,116-218,893,928 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 8 phenotypes. Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal Cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

WNT10A Products(1)

mRNA	Protein	Name
NM_025216.3	NP_079492.2	protein Wnt-10a precursor

WNT10A Protein Structure

wnt

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

protein Wnt-10a

wingless-type MMTV integration site family, member 10A

Related Diseases

Diseases

Alias

Odontoonychodermal Dysplasia

Odonto-Onycho-Dermal Dysplasia	OODD
Ectodermal Dysplasia 16, Hypo- Or Hyperhidrotic/Hair/Tooth/Nail Type	Ectd16
Tricho-Odonto-Onycho-Dermal Dysplasia	Dysplasia, Odontoonychodermal

Schopf-Schulz-Passarge Syndrome

SSPS	Eccrine Tumors With Ectodermal Dysplasia
Eccrine Tumors-Ectodermal Dysplasia	Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome	Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis	Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis

Tooth Agenesis, Selective, 4

STHAG4	Tooth Agenesis, Selective, 4, With Or Without Ectodermal Dysplasia
Lateral Incisors, Absence Of	Lateral Incisors, Pegged Or Missing
Succedaneous Teeth, Agenesis Of	Absence Of Lateral Incisors
Agenesis Of Succedaneous Teeth	Pegged Or Missing Lateral Incisors
Selective Tooth Agenesis 4

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia	Hed
Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic
Eda	Christ-Siemens-Touraine Syndrome
ECTD10B	Ectodermal Dysplasia Anhidrotic
Ectodermal Dysplasia, Anhidrotic	Cst Syndrome
Ectodermal Dysplasia Hypohidrotic Autosomal Recessive	Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive
Dysplasia, Ectodermal, Hypohidrotic	Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive
Ectodermal Dysplasia 3, Anhidrotic	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Hypohidrotic Ectodermal Dysplasia Autosomal Recessive

Anhidrotic Ectodermal Dysplasia, Autosomal Recessive	Autosomal Recessive Hypohidrotic Ectodermal Dysplasia
Ar-Hed	Autosomal Recessive Anhidrotic Ectodermal Dysplasia
Autosomal Recessive Hypohidrotic Ectodermal Dysplasia Syndrome	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Ectodermal Dysplasia 13, Hair/Tooth Type

ECTD13

Ectodermal Dysplasia 13

Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

Christ-Siemens-Touraine Syndrome	XHED
Ectodermal Dysplasia 1	Xlhed
Ed1	Cst Syndrome
Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked	Ectd1
Ectodermal Dysplasia, Anhidrotic, X-Linked	Eda
Eda1	Hed1
Ectodermal Dysplasia 1, Anhidrotic	X-Linked Anhidrotic Ectodermal Dysplasia
X-Linked Hypohidrotic Ectodermal Dysplasia	Hypohidrotic X-Linked Ectodermal Dysplasia
Ectodermal Dysplasia, Hypohidrotic, 1	Hypohidrotic Ectodermal Dysplasia, X-Linked
Anhidrotic Ectodermal Dysplasia X-Linked	Hypohidrotic Ectodermal Dysplasia X-Linked
Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked	Ectodermal Dysplasia Anhidrotic

Anodontia

Complete Absence Of Teeth	Developmental Absence Of Tooth
Total Anodontia Of Permanent And Deciduous Teeth	Absence Of Permanent Teeth
Anodontia Of Permanent Dentition	Agomphiasis
Agomphosis	Anodontism
Complete Developmental Absence Of Teeth	Congenital Absence Of Teeth
Congenital Complete Absence Of Teeth	Congenital Edentia
Absence Of Teeth	Absent Teeth
Congenital Partial Absence Of Teeth	Partial Absence Of Teeth
Partial Anodontia

Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly

Fuhrmann Syndrome	Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies
Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome	Fuhrmann-Rieger-De Sousa Syndrome
FUHRS	Fibular Aplasia
Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly

Hypotrichosis

Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive

ECTD11B	Hed
Eda	Ectodermal Dysplasia 11b
Ectodermal Dysplasia, Hypohidrotic	Ectodermal Dysplasia, Anhidrotic
Ectodermal Dysplasia Anhidrotic	Ectodermal Dysplasia Hypohidrotic Autosomal Recessive
Dysplasia, Ectodermal, Type 11b, Hypohidrotic/Hair/Tooth, Autosomal Recessive	Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome	Aarrs
Limb/Pelvis-Hypoplasia/Aplasia Syndrome	LPHAS
Schinzel Type Phocomelia	Absence Of Ulna And Fibula With Severe Limb Deficiency
Al-Awadi/Raas-Rothschild Syndrome	Al Awadi-Raas-Rothschild Syndrome
Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome	Aplasia/Hypoplasia Of Limbs And Pelvis
Congenital Absence Of Ulna And Fibula	Severe Limb Deficit
Phocomelia, Schinzel Type	Al-Awadi-Raas-Rothschild Syndrome
Ulna And Fibula Absence Of With Severe Limb Deficiency	Limb Pelvis Hypoplasia Aplasia Syndrome
Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome	Ulna And Fibula, Absence Of, With Sever Limb Deficiency

Hidrocystoma

Apocrine Cystadenoma	Eccrine Hidrocystoma
Eccrine Cystadenoma	Eccrine Hidrocystoma Of Skin
Apocrine Adenoma

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Orofacial Cleft

Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15828	WNT10A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNT10A	MGD	MGI:108071
Bos taurus	WNT10A	VGNC	VGNC:36954
Rattus norvegicus	WNT10A	RGD	RGD:1307015
Felis catus	WNT10A	VGNC	VGNC:107689
Macaca mulatta	WNT10A	VGNC	VGNC:104564
Canis familiaris	WNT10A	VGNC	VGNC:48420

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