Gatm - glycine amidinotransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81660

Summary

Enables amidinotransferase activity. Involved in several processes, including embryonic liver development; response to mercury ion; and response to peptide hormone. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase). [provided by Alliance of Genome Resources, Apr 2022]

Gatm Products (1)

mRNA Protein Name
NM_031031.2 NP_112293.1 glycine amidinotransferase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amidinotransferase activity IDA
IDA: Inferred from direct assay
8035648 RGD
enables glycine amidinotransferase activity IDA
IDA: Inferred from direct assay
2257950 RGD
Biological Process GO Annotation Evidence References Source
involved in embryonic liver development IEP
IEP: Inferred from expression pattern
15918910 RGD
involved in kidney development IDA
IDA: Inferred from direct assay
4027351 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
205820 RGD
involved in response to flavonoid IDA
IDA: Inferred from direct assay
15600250 RGD
involved in response to mercury ion IDA
IDA: Inferred from direct assay
15600250 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
11595668 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
8837048 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8021264 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
16626512 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
2257950 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
1140432 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
2257950 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycine amidinotransferase, mitochondrial

  • AT

  • L-arginine: glycine amidinotransferase

  • l-arginine:glycine amidinotransferase

  • transamidinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19134 Gatm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05300 GATM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25624 Gatm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gatm NCBI NCBI:2628