FZD4 - frizzled class receptor 4 Gene

Also Known as Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8322

About FZD4

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,945,679-86,955,395 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues, 15 paralogues and is associated with 5 phenotypes. Broad expression in fat (RPKM 98.6), kidney (RPKM 18.6) and 14 other tissues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by Other experimental evidence. [provided by RefSeq, Jul 2008]

FZD4 Products (1)

mRNA	Protein	Name
NM_012193.4	NP_036325.2	frizzled-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	20802536	GOA
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	19388021	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	17955262	GOA
enables cytokine receptor activity	IDA IDA: Inferred from direct assay	17955262	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17955262	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	18234671	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22575959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Norrin signaling pathway	IDA IDA: Inferred from direct assay	15035989	GOA
involved in Wnt signaling pathway, calcium modulating pathway	IDA IDA: Inferred from direct assay	12172548	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14688793	GOA
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18156211	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14688793	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15035989	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22057916	GOA
involved in retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	12172548	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19643732	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12172548	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD4 Protein Structure

Frizzled

0
100
200
300
400
500
537 a.a.

Protein Preferred Names	Protein Names
frizzled-4	WNT receptor frizzled-4

FZD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	NDP	Homo sapiens	Q00604	Imaging	17955262
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	FZD4	Q9ULV1	A2M	Homo sapiens	P01023	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74140	Frizzled-4/CD344 Protein, Human (HEK293, His)	Q9ULV1 (F37-E180)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74141	Frizzled-4/CD344 Protein, Human (HEK293, Fc)	Q9ULV1 (F37-E180)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Persistent Hyperplastic Primary Vitreous	Congenital Retinal Detachment Ncrna Disease Non-Syndromic Congenital Retinal Non-Attachment Pfvs Phpv Persistent Fetal Vasculature Syndrome
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Vitreoretinopathy
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Leukocoria	Leucocoria
Retinal Telangiectasia
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Retinal Vascular Disease	Retinal Vascular Retinal Vascular Disorder Retina Circulation Disorder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Vitreous Disease	Disorder Of Vitreous Body
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117163	FzM1.8	Agonist	98.93%	Unkown
HY-116553	FzM1	Inhibitor	98.72%	Unkown
HY-181160	JNK3/Wnt/β-catenin modulator-1		/	Unkown
HY-RS05180	FZD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17330	Fzd4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23785	Fzd4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992126	Remigromig	Inhibitor	95.25%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FZD4	VGNC	VGNC:72836
Felis catus	FZD4	VGNC	VGNC:102891
Mus musculus	FZD4	MGD	MGI:108520
Canis familiaris	FZD4	VGNC	VGNC:41032
Rattus norvegicus	FZD4	RGD	RGD:71017
Bos taurus	FZD4	VGNC	VGNC:29168
Others	FZD4	NCBI